V2462

antibody from NSJ Bioreagents

Targeting: CCR5 CC-CKR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

V2462

Provider

NSJ Bioreagents

Product name

CCR5 Antibody

Antibody type

Monoclonal

Antigen

Human native protein was used as the immunogen for the CCR5 antibody.

Description

Protein G purified antibody

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

12D1

Vial size

20 µg, 100 µg (with sodium azide), 100 µg (without sodium azide), 7 ml (prediluted for IHC use, if applicable)

Storage

Store the CCR5 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

References

Submitted references

Monoclonal antibody-assisted stimulation of adenosine A2A receptors induces simultaneous downregulation of CXCR4 and CCR5 on CD4+ T-cells.

By Y, Durand-Gorde JM, Condo J, Lejeune PJ, Fenouillet E, Guieu R, Ruf J
Human immunology 2010 Nov;71(11):1073-6

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Human herpesvirus 6A decreases the susceptibility of macrophages to R5 variants of human immunodeficiency virus 1: possible role of RANTES and IL-8.

Csoma E, Deli T, Kónya J, Csernoch L, Beck Z, Gergely L
Virus research 2006 Nov;121(2):161-8

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Molecular modeling and site-directed mutagenesis of CCR5 reveal residues critical for chemokine binding and signal transduction.

Zhou N, Luo Z, Hall JW, Luo J, Han X, Huang Z
European journal of immunology 2000 Jan;30(1):164-73

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The anti-HIV pseudopeptide HB-19 forms a complex with the cell-surface-expressed nucleolin independent of heparan sulfate proteoglycans.

Nisole S, Krust B, Callebaut C, Guichard G, Muller S, Briand JP, Hovanessian AG
The Journal of biological chemistry 1999 Sep 24;274(39):27875-84

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CCR5 HIV-1 coreceptor activity. Role of cooperativity between residues in N-terminal extracellular and intracellular domains.

Wang Z, Lee B, Murray JL, Bonneau F, Sun Y, Schweickart V, Zhang T, Peiper SC
The Journal of biological chemistry 1999 Oct 1;274(40):28413-9

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The V3 loop-mimicking pseudopeptide 5[Kpsi(CH2N)PR]-TASP inhibits HIV infection in primary macrophage cultures.

Seddiki N, Nisole S, Krust B, Callebaut C, Guichard G, Muller S, Briand JP, Hovanessian AG
AIDS research and human retroviruses 1999 Mar 1;15(4):381-90

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CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins.

Wang ZX, Berson JF, Zhang TY, Cen YH, Sun Y, Sharron M, Lu ZH, Peiper SC
The Journal of biological chemistry 1998 Jun 12;273(24):15007-15