NBL1

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

Description

NBL1, DAN family BMP antagonist

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (19596979 - 19658456)

Ensembl ID

ENSG00000158747  (ver. 103.38)

Orthologs

Mouse Nbl1: ENSMUSG00000041120

UniProt

P41271

neXtProt

NX_P41271

Human splice variants
Mouse splice variants

Protein structure