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- Antibody Data
- Antigen structure
- References [141]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 10795-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10795-1-AP, RRID:AB_2185480
- Product name
- Sestrin 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Sestrin 2 antibody (Cat. #10795-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sestrin2 Regulates Osteoclastogenesis via the p62-TRAF6 Interaction.
Study of the Mechanism by Which Curcumin Cooperates with Sestrin2 to Inhibit the Growth of Pancreatic Cancer.
Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload.
p53 induces a survival transcriptional response after nucleolar stress.
The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
Upregulation Sestrin2 protects against hydrogen peroxide-induced oxidative damage bovine mammary epithelial cells via a Keap1-Nrf2/ARE pathway.
Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.
Pharmacokinetic Analysis of Carnosic Acid and Carnosol in Standardized Rosemary Extract and the Effect on the Disease Activity Index of DSS-Induced Colitis.
Sestrin 2 protects against LPS-induced acute lung injury by inducing mitophagy in alveolar macrophages.
SAR1B senses leucine levels to regulate mTORC1 signalling.
The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes.
CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina.
Daily protein supplementation attenuates immobilization-induced blunting of postabsorptive muscle mTORC1 activation in middle-aged men.
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Treatment of ErbB2 breast cancer by mitochondrial targeting.
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer.
mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer.
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Correlation between sestrin2 expression and airway remodeling in COPD.
GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.
Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway.
ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation.
Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy.
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Systematic quantitative analysis of ribosome inventory during nutrient stress.
Sestrin2 modulates cardiac inflammatory response through maintaining redox homeostasis during ischemia and reperfusion.
Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity.
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals.
The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.
Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity via the activation of the Sesn2/AMPK/Nrf2 signaling pathway.
Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress.
Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism.
Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury.
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis.
Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.
Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity.
Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling.
p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.
Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK.
Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2.
RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.
Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis.
The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells.
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Sestrin2 regulates monocyte activation through AMPK-mTOR nexus under high-glucose and dyslipidemic conditions.
The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle.
Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-κB and activation of nuclear factor erythroid 2-related factor 2.
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway.
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax.
Sestrin2 facilitates glutamine-dependent transcription of PGC-1α and survival of liver cancer cells under glucose limitation.
Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.
Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism.
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.
Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes.
Sestrin2 protects against acetaminophen-induced liver injury.
SZT2 dictates GATOR control of mTORC1 signalling.
Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury.
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes.
5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells.
Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle.
Compound C Increases Sestrin2 Expression via Mitochondria-Dependent ROS Production.
The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.
Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.
Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.
Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.
p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.
p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.
Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons.
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.
Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.
Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.
Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
Sestrin2-AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity.
Role of sestrin2 in the regulation of proinflammatory signaling in macrophages.
Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.
Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.
The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation.
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.
Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.
Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.
Hepatoprotective role of Sestrin2 against chronic ER stress.
p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.
Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.
Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.
Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.
Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.
The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.
Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.
The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.
Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.
Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.
Mechanisms involved in alternariol-induced cell cycle arrest.
Highly reactive meso-like positions of dipyrihexaphyrin.
Nrf2-ARE pathway regulates induction of Sestrin-2 expression.
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.
Role of sestrin2 in peroxide signaling in macrophages.
Artemis is a negative regulator of p53 in response to oxidative stress.
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.
Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.
A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell.
Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure.
Oh SY, Kang N, Kang JY, Kim KW, Choi JH, Yang YM, Shin DM
Frontiers in cell and developmental biology 2021;9:646803
Frontiers in cell and developmental biology 2021;9:646803
Study of the Mechanism by Which Curcumin Cooperates with Sestrin2 to Inhibit the Growth of Pancreatic Cancer.
Fu H, Ni X, Ni F, Li D, Sun H, Kong H, Shan Y, Dai S
Gastroenterology research and practice 2021;2021:7362233
Gastroenterology research and practice 2021;2021:7362233
Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload.
Zhang N, Liao HH, Feng H, Mou SQ, Li WJ, Aiyasiding X, Lin Z, Ding W, Zhou ZY, Yan H, Chen S, Tang QZ
Frontiers in pharmacology 2021;12:716884
Frontiers in pharmacology 2021;12:716884
p53 induces a survival transcriptional response after nucleolar stress.
Liao H, Gaur A, Mauvais C, Denicourt C
Molecular biology of the cell 2021 Oct 1;32(20):ar3
Molecular biology of the cell 2021 Oct 1;32(20):ar3
The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.
Hsieh YH, Chao AC, Lin YC, Chen SD, Yang DI
Free radical biology & medicine 2021 Jun;169:36-61
Free radical biology & medicine 2021 Jun;169:36-61
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Liu X, Li M, Zhu J, Huang W, Song J
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin.
Jang SK, Hong SE, Lee DH, Kim JY, Kim JY, Ye SK, Hong J, Park IC, Jin HO
BMC cancer 2021 Jul 12;21(1):803
BMC cancer 2021 Jul 12;21(1):803
Upregulation Sestrin2 protects against hydrogen peroxide-induced oxidative damage bovine mammary epithelial cells via a Keap1-Nrf2/ARE pathway.
Chen M, Xi Y, Chen K, Xiao P, Li S, Sun X, Han Z
Journal of cellular physiology 2021 Jan;236(1):392-404
Journal of cellular physiology 2021 Jan;236(1):392-404
Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.
Kim SH, Choi JH, Wang P, Go CD, Hesketh GG, Gingras AC, Jafarnejad SM, Sonenberg N
Molecular cell 2021 Jan 21;81(2):398-407.e4
Molecular cell 2021 Jan 21;81(2):398-407.e4
Pharmacokinetic Analysis of Carnosic Acid and Carnosol in Standardized Rosemary Extract and the Effect on the Disease Activity Index of DSS-Induced Colitis.
Veenstra JP, Vemu B, Tocmo R, Nauman MC, Johnson JJ
Nutrients 2021 Feb 27;13(3)
Nutrients 2021 Feb 27;13(3)
Sestrin 2 protects against LPS-induced acute lung injury by inducing mitophagy in alveolar macrophages.
Wu D, Zhang H, Wu Q, Li F, Wang Y, Liu S, Wang J
Life sciences 2021 Feb 15;267:118941
Life sciences 2021 Feb 15;267:118941
SAR1B senses leucine levels to regulate mTORC1 signalling.
Chen J, Ou Y, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen PR, Liu Y
Nature 2021 Aug;596(7871):281-284
Nature 2021 Aug;596(7871):281-284
The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes.
Sawa R, Wake I, Yamamoto Y, Okimura Y
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2021 Aug;59:101406
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2021 Aug;59:101406
CERKL, a retinal dystrophy gene, regulates mitochondrial function and dynamics in the mammalian retina.
Mirra S, García-Arroyo R, B Domènech E, Gavaldà-Navarro A, Herrera-Úbeda C, Oliva C, Garcia-Fernàndez J, Artuch R, Villarroya F, Marfany G
Neurobiology of disease 2021 Aug;156:105405
Neurobiology of disease 2021 Aug;156:105405
Daily protein supplementation attenuates immobilization-induced blunting of postabsorptive muscle mTORC1 activation in middle-aged men.
Zeng N, D'Souza RF, MacRae CL, Figueiredo VC, Pileggi CA, Markworth JF, Merry TL, Cameron-Smith D, Mitchell CJ
American journal of physiology. Cell physiology 2021 Apr 1;320(4):C591-C601
American journal of physiology. Cell physiology 2021 Apr 1;320(4):C591-C601
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Zhang J, Jiang D, Lin S, Cheng Y, Pan J, Ding W, Chen Y, Fan J
Life sciences 2021 Apr 1;270:119131
Life sciences 2021 Apr 1;270:119131
Treatment of ErbB2 breast cancer by mitochondrial targeting.
Eldad S, Hertz R, Vainer G, Saada A, Bar-Tana J
Cancer & metabolism 2020;8:17
Cancer & metabolism 2020;8:17
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Du J, He W, Zhang C, Wu J, Li Z, Wang M, Feng S, Liang G
BioMed research international 2020;2020:3243906
BioMed research international 2020;2020:3243906
PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis.
Lim JT, Singh N, Leuvano LA, Calvert VS, Petricoin EF, Teachey DT, Lock RB, Padi M, Kraft AS, Padi SKR
Molecular cancer therapeutics 2020 Sep;19(9):1809-1821
Molecular cancer therapeutics 2020 Sep;19(9):1809-1821
Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer.
Recouvreux MV, Moldenhauer MR, Galenkamp KMO, Jung M, James B, Zhang Y, Lowy A, Bagchi A, Commisso C
The Journal of experimental medicine 2020 Sep 7;217(9)
The Journal of experimental medicine 2020 Sep 7;217(9)
mTOR-Dependent Role of Sestrin2 in Regulating Tumor Progression of Human Endometrial Cancer.
Shin J, Bae J, Park S, Kang HG, Shin SM, Won G, Kim JS, Cho SG, Choi Y, Oh SM, Shin J, Kim JS, Park HW
Cancers 2020 Sep 4;12(9)
Cancers 2020 Sep 4;12(9)
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Li Y, Wu J, Yu S, Zhu J, Zhou Y, Wang P, Li L, Zhao Y
Brain research 2020 Oct 15;1745:146948
Brain research 2020 Oct 15;1745:146948
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Lee DH, Park JS, Lee YS, Han J, Lee DK, Kwon SW, Han DH, Lee YH, Bae SH
Autophagy 2020 Nov;16(11):1949-1973
Autophagy 2020 Nov;16(11):1949-1973
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Ding S, Ma N, Liu H, Tang M, Mei J
Aging 2020 Nov 24;12(24):25505-25527
Aging 2020 Nov 24;12(24):25505-25527
Correlation between sestrin2 expression and airway remodeling in COPD.
Zhang DW, Wei YY, Ji S, Fei GH
BMC pulmonary medicine 2020 Nov 16;20(1):297
BMC pulmonary medicine 2020 Nov 16;20(1):297
GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.
Kanno A, Asahara SI, Furubayashi A, Masuda K, Yoshitomi R, Suzuki E, Takai T, Kimura-Koyanagi M, Matsuda T, Bartolome A, Hirota Y, Yokoi N, Inaba Y, Inoue H, Matsumoto M, Inoue K, Abe T, Wei FY, Tomizawa K, Ogawa W, Seino S, Kasuga M, Kido Y
JCI insight 2020 May 7;5(9)
JCI insight 2020 May 7;5(9)
Liraglutide ameliorates obesity-related nonalcoholic fatty liver disease by regulating Sestrin2-mediated Nrf2/HO-1 pathway.
Han X, Ding C, Zhang G, Pan R, Liu Y, Huang N, Hou N, Han F, Xu W, Sun X
Biochemical and biophysical research communications 2020 May 14;525(4):895-901
Biochemical and biophysical research communications 2020 May 14;525(4):895-901
ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation.
Xu D, Dai W, Kutzler L, Lacko HA, Jefferson LS, Dennis MD, Kimball SR
The Journal of nutrition 2020 May 1;150(5):1022-1030
The Journal of nutrition 2020 May 1;150(5):1022-1030
Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy.
Qi W, Li Z, Yang C, Jiangshan Dai J, Zhang Q, Wang D, Wu C, Xia L, Xu S
Oncology reports 2020 Mar;43(3):839-850
Oncology reports 2020 Mar;43(3):839-850
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Fan Y, Xing Y, Xiong L, Wang J
Chemico-biological interactions 2020 Jun 1;324:109086
Chemico-biological interactions 2020 Jun 1;324:109086
Systematic quantitative analysis of ribosome inventory during nutrient stress.
An H, Ordureau A, Körner M, Paulo JA, Harper JW
Nature 2020 Jul;583(7815):303-309
Nature 2020 Jul;583(7815):303-309
Sestrin2 modulates cardiac inflammatory response through maintaining redox homeostasis during ischemia and reperfusion.
Ren D, Quan N, Fedorova J, Zhang J, He Z, Li J
Redox biology 2020 Jul;34:101556
Redox biology 2020 Jul;34:101556
Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.
Jegal KH, Kim EO, Kim JK, Park SM, Jung DH, Lee GH, Ki SH, Byun SH, Ku SK, Cho IJ, Kim SC
Toxicology and applied pharmacology 2020 Jul 15;399:115036
Toxicology and applied pharmacology 2020 Jul 15;399:115036
Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.
Li W, Jiang YH, Wang Y, Zhao M, Hou GJ, Hu HZ, Zhou L
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Chinese journal of integrative medicine 2020 Jan;26(1):46-53
Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity.
Vivas-García Y, Falletta P, Liebing J, Louphrasitthiphol P, Feng Y, Chauhan J, Scott DA, Glodde N, Chocarro-Calvo A, Bonham S, Osterman AL, Fischer R, Ronai Z, García-Jiménez C, Hölzel M, Goding CR
Molecular cell 2020 Jan 2;77(1):120-137.e9
Molecular cell 2020 Jan 2;77(1):120-137.e9
Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals.
Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Hee Lee J, Muñoz-Cánoves P
Nature communications 2020 Jan 13;11(1):189
Nature communications 2020 Jan 13;11(1):189
The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
Kowalsky AH, Namkoong S, Mettetal E, Park HW, Kazyken D, Fingar DC, Lee JH
The Journal of biological chemistry 2020 Feb 14;295(7):1769-1780
The Journal of biological chemistry 2020 Feb 14;295(7):1769-1780
Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.
Hwang CY, Han YH, Lee SM, Cho SM, Yu DY, Kwon KS
Annals of geriatric medicine and research 2020 Dec;24(4):297-304
Annals of geriatric medicine and research 2020 Dec;24(4):297-304
Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity via the activation of the Sesn2/AMPK/Nrf2 signaling pathway.
Yang D, Han B, Baiyun R, Lv Z, Wang X, Li S, Lv Y, Xue J, Liu Y, Zhang Z
Metallomics : integrated biometal science 2020 Dec 23;12(12):2009-2020
Metallomics : integrated biometal science 2020 Dec 23;12(12):2009-2020
Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress.
Kim H, Jeon BT, Kim IM, Bennett SJ, Lorch CM, Viana MP, Myers JF, Trupp CJ, Whipps ZT, Kundu M, Chung S, Sun X, Khalimonchuk O, Lee J, Ro SH
International journal of molecular sciences 2020 Aug 25;21(17)
International journal of molecular sciences 2020 Aug 25;21(17)
Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism.
Rajanala SH, Ringquist R, Cryns VL
American journal of cancer research 2019;9(8):1766-1775
American journal of cancer research 2019;9(8):1766-1775
Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury.
Park SJ, Cho SS, Kim KM, Yang JH, Kim JH, Jeong EH, Yang JW, Han CY, Ku SK, Cho IJ, Ki SH
Toxicology and applied pharmacology 2019 Sep 15;379:114665
Toxicology and applied pharmacology 2019 Sep 15;379:114665
Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle.
Xu D, Shimkus KL, Lacko HA, Kutzler L, Jefferson LS, Kimball SR
American journal of physiology. Endocrinology and metabolism 2019 May 1;316(5):E817-E828
American journal of physiology. Endocrinology and metabolism 2019 May 1;316(5):E817-E828
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Park JS, Lee YS, Lee DH, Bae SH
Free radical biology & medicine 2019 Jun;137:143-157
Free radical biology & medicine 2019 Jun;137:143-157
Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis.
Yang JH, Kim KM, Cho SS, Shin SM, Ka SO, Na CS, Park BH, Jegal KH, Kim JK, Ku SK, Lee HJ, Park SG, Cho IJ, Ki SH
Antioxidants & redox signaling 2019 Jul 20;31(3):243-259
Antioxidants & redox signaling 2019 Jul 20;31(3):243-259
Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.
Wang P, Zhao Y, Li Y, Wu J, Yu S, Zhu J, Li L, Zhao Y
Neuroscience 2019 Jul 1;410:140-149
Neuroscience 2019 Jul 1;410:140-149
Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity.
Li R, Huang Y, Semple I, Kim M, Zhang Z, Lee JH
American journal of physiology. Heart and circulatory physiology 2019 Jul 1;317(1):H39-H48
American journal of physiology. Heart and circulatory physiology 2019 Jul 1;317(1):H39-H48
Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling.
Xia J, Zeng W, Xia Y, Wang B, Xu D, Liu D, Kong MG, Dong Y
Journal of biophotonics 2019 Jan;12(1):e201800046
Journal of biophotonics 2019 Jan;12(1):e201800046
p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.
Ding B, Haidurov A, Chawla A, Parmigiani A, van de Kamp G, Dalina A, Yuan F, Lee JH, Chumakov PM, Grossman SR, Budanov AV
Oncotarget 2019 Dec 10;10(65):6997-7009
Oncotarget 2019 Dec 10;10(65):6997-7009
Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK.
Jin HR, Du CH, Wang CZ, Yuan CS, Du W
Cell death & disease 2019 Apr 5;10(4):311
Cell death & disease 2019 Apr 5;10(4):311
Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2.
Jung JY, Park SM, Ko HL, Lee JR, Park CA, Byun SH, Ku SK, Cho IJ, Kim SC
The American journal of Chinese medicine 2018;46(2):469-488
The American journal of Chinese medicine 2018;46(2):469-488
RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.
Kumar A, Shaha C
Molecular and cellular biochemistry 2018 Sep;446(1-2):1-9
Molecular and cellular biochemistry 2018 Sep;446(1-2):1-9
Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis.
Zeng N, D'Souza RF, Mitchell CJ, Cameron-Smith D
Experimental gerontology 2018 Sep;110:23-34
Experimental gerontology 2018 Sep;110:23-34
The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells.
Zheng Y, Lei Q, Jongejan A, Mulder CL, van Daalen SKM, Mastenbroek S, Hwang G, Jordan PW, Repping S, Hamer G
DNA repair 2018 Oct;70:55-66
DNA repair 2018 Oct;70:55-66
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Wang T, Niu Y, Liu S, Yuan H, Liu X, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3368-3377
Biochimica et biophysica acta. Molecular basis of disease 2018 Oct;1864(10):3368-3377
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Dai J, Huang Q, Niu K, Wang B, Li Y, Dai C, Chen Z, Tao K, Dai J
Cancer medicine 2018 Nov;7(11):5691-5703
Cancer medicine 2018 Nov;7(11):5691-5703
Sestrin2 regulates monocyte activation through AMPK-mTOR nexus under high-glucose and dyslipidemic conditions.
Sundararajan S, Jayachandran I, Balasubramanyam M, Mohan V, Venkatesan B, Manickam N
Journal of cellular biochemistry 2018 Nov 18;
Journal of cellular biochemistry 2018 Nov 18;
The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle.
Zeng N, D'Souza RF, Sorrenson B, Merry TL, Barnett MPG, Mitchell CJ, Cameron-Smith D
European journal of applied physiology 2018 Jun;118(6):1241-1253
European journal of applied physiology 2018 Jun;118(6):1241-1253
Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-κB and activation of nuclear factor erythroid 2-related factor 2.
Kim JK, Lee JE, Jung EH, Jung JY, Jung DH, Ku SK, Cho IJ, Kim SC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Jan;111:176-188
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Jan;111:176-188
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.
Kumar A, Shaha C
Scientific reports 2018 Jan 12;8(1):615
Scientific reports 2018 Jan 12;8(1):615
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway.
Quan N, Wang L, Chen X, Luckett C, Cates C, Rousselle T, Zheng Y, Li J
Journal of molecular and cellular cardiology 2018 Feb;115:170-178
Journal of molecular and cellular cardiology 2018 Feb;115:170-178
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Shin D, Kim EH, Lee J, Roh JL
Free radical biology & medicine 2018 Dec;129:454-462
Free radical biology & medicine 2018 Dec;129:454-462
Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax.
Florean C, Kim KR, Schnekenburger M, Kim HJ, Moriou C, Debitus C, Dicato M, Al-Mourabit A, Han BW, Diederich M
Marine drugs 2018 Dec 19;16(12)
Marine drugs 2018 Dec 19;16(12)
Sestrin2 facilitates glutamine-dependent transcription of PGC-1α and survival of liver cancer cells under glucose limitation.
Kumar A, Giri S, Shaha C
The FEBS journal 2018 Apr;285(7):1326-1345
The FEBS journal 2018 Apr;285(7):1326-1345
Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.
Ebnoether E, Ramseier A, Cortada M, Bodmer D, Levano-Huaman S
Cell death discovery 2017;3:17024
Cell death discovery 2017;3:17024
Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism.
Quan N, Sun W, Wang L, Chen X, Bogan JS, Zhou X, Cates C, Liu Q, Zheng Y, Li J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Sep;31(9):4153-4167
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Sep;31(9):4153-4167
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
Kim HJ, Joe Y, Kim SK, Park SU, Park J, Chen Y, Kim J, Ryu J, Cho GJ, Surh YJ, Ryter SW, Kim UH, Chung HT
Free radical biology & medicine 2017 Sep;110:81-91
Free radical biology & medicine 2017 Sep;110:81-91
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Zhang C, Sun W, Li J, Xiong B, Frye MD, Ding D, Salvi R, Kim MJ, Someya S, Hu BH
Neuroscience 2017 Oct 11;361:179-191
Neuroscience 2017 Oct 11;361:179-191
Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.
Tomasovic A, Kurrle N, Wempe F, De-Zolt S, Scheibe S, Koli K, Serchinger M, Schnütgen F, Sürün D, Sterner-Kock A, Weissmann N, von Melchner H
Matrix biology : journal of the International Society for Matrix Biology 2017 May;59:109-120
Matrix biology : journal of the International Society for Matrix Biology 2017 May;59:109-120
Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes.
Li H, Liu S, Yuan H, Niu Y, Fu L
Experimental cell research 2017 May 1;354(1):18-24
Experimental cell research 2017 May 1;354(1):18-24
Sestrin2 protects against acetaminophen-induced liver injury.
Kim SJ, Kim KM, Yang JH, Cho SS, Kim JY, Park SJ, Lee SK, Ku SK, Cho IJ, Ki SH
Chemico-biological interactions 2017 May 1;269:50-58
Chemico-biological interactions 2017 May 1;269:50-58
SZT2 dictates GATOR control of mTORC1 signalling.
Peng M, Yin N, Li MO
Nature 2017 Mar 16;543(7645):433-437
Nature 2017 Mar 16;543(7645):433-437
Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.
Xing Y, Liu YX, Liu X, Wang SL, Li P, Lin XH, Sui CL, Xu C, Qi B, Tong Q
Experimental and therapeutic medicine 2017 Jun;13(6):3567-3573
Experimental and therapeutic medicine 2017 Jun;13(6):3567-3573
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury.
Jegal KH, Park SM, Cho SS, Byun SH, Ku SK, Kim SC, Ki SH, Cho IJ
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1295-1307
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1295-1307
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Byun JK, Choi YK, Kim JH, Jeong JY, Jeon HJ, Kim MK, Hwang I, Lee SY, Lee YM, Lee IK, Park KG
Cell reports 2017 Jul 18;20(3):586-599
Cell reports 2017 Jul 18;20(3):586-599
Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes.
Zhao B, Shah P, Qiang L, He TC, Budanov A, He YY
Photochemistry and photobiology 2017 Jan;93(1):375-381
Photochemistry and photobiology 2017 Jan;93(1):375-381
5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells.
Seo K, Ki SH, Park EY, Shin SM
Archives of pharmacal research 2017 Feb;40(2):231-239
Archives of pharmacal research 2017 Feb;40(2):231-239
Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle.
Zeng N, D'Souza RF, Figueiredo VC, Markworth JF, Roberts LA, Peake JM, Mitchell CJ, Cameron-Smith D
Physiological reports 2017 Dec;5(24)
Physiological reports 2017 Dec;5(24)
Compound C Increases Sestrin2 Expression via Mitochondria-Dependent ROS Production.
Seo K, Seo S, Ki SH, Shin SM
Biological & pharmaceutical bulletin 2016;39(5):799-806
Biological & pharmaceutical bulletin 2016;39(5):799-806
The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.
Mlitz V, Gendronneau G, Berlin I, Buchberger M, Eckhart L, Tschachler E
PloS one 2016;11(11):e0166832
PloS one 2016;11(11):e0166832
Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.
Jegal KH, Ko HL, Park SM, Byun SH, Kang KW, Cho IJ, Kim SC
Apoptosis : an international journal on programmed cell death 2016 May;21(5):642-56
Apoptosis : an international journal on programmed cell death 2016 May;21(5):642-56
Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.
Sun W, Quan N, Wang L, Yang H, Chu D, Liu Q, Zhao X, Leng J, Li J
Toxicological sciences : an official journal of the Society of Toxicology 2016 May;151(1):193-203
Toxicological sciences : an official journal of the Society of Toxicology 2016 May;151(1):193-203
Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.
Reddy K, Cusack CL, Nnah IC, Khayati K, Saqcena C, Huynh TB, Noggle SA, Ballabio A, Dobrowolski R
Cell reports 2016 Mar 8;14(9):2166-2179
Cell reports 2016 Mar 8;14(9):2166-2179
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.
Ding B, Parmigiani A, Divakaruni AS, Archer K, Murphy AN, Budanov AV
Scientific reports 2016 Mar 2;6:22538
Scientific reports 2016 Mar 2;6:22538
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.
Li L, Xiao L, Hou Y, He Q, Zhu J, Li Y, Wu J, Zhao J, Yu S, Zhao Y
Scientific reports 2016 Jul 25;6:30272
Scientific reports 2016 Jul 25;6:30272
p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
Agarwal S, Bell CM, Taylor SM, Moran RG
Molecular cancer research : MCR 2016 Jan;14(1):66-77
Molecular cancer research : MCR 2016 Jan;14(1):66-77
Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.
Ro SH, Xue X, Ramakrishnan SK, Cho CS, Namkoong S, Jang I, Semple IA, Ho A, Park HW, Shah YM, Lee JH
eLife 2016 Feb 25;5:e12204
eLife 2016 Feb 25;5:e12204
p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
Park JS, Oh SY, Lee DH, Lee YS, Sung SH, Ji HW, Lee MJ, Lee YH, Rhee SG, Bae SH
Free radical research 2016 Dec;50(12):1408-1421
Free radical research 2016 Dec;50(12):1408-1421
Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.
Seo K, Seo S, Ki SH, Shin SM
Free radical biology & medicine 2016 Dec;101:511-523
Free radical biology & medicine 2016 Dec;101:511-523
Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons.
Wu CL, Chen SD, Yin JH, Hwang CS, Yang DI
Molecular neurobiology 2016 Aug;53(6):4126-4142
Molecular neurobiology 2016 Aug;53(6):4126-4142
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.
Kimball SR, Gordon BS, Moyer JE, Dennis MD, Jefferson LS
Cellular signalling 2016 Aug;28(8):896-906
Cellular signalling 2016 Aug;28(8):896-906
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.
Kim MJ, Bae SH, Ryu JC, Kwon Y, Oh JH, Kwon J, Moon JS, Kim K, Miyawaki A, Lee MG, Shin J, Kim YS, Kim CH, Ryter SW, Choi AM, Rhee SG, Ryu JH, Yoon JH
Autophagy 2016 Aug 2;12(8):1272-91
Autophagy 2016 Aug 2;12(8):1272-91
Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.
Chai D, Wang G, Zhou Z, Yang H, Yu Z
International journal of endocrinology 2015;2015:505849
International journal of endocrinology 2015;2015:505849
Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.
Ding B, Parmigiani A, Yang C, Budanov AV
Cell cycle (Georgetown, Tex.) 2015;14(20):3231-41
Cell cycle (Georgetown, Tex.) 2015;14(20):3231-41
Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.
Kimball SR, Ravi S, Gordon BS, Dennis MD, Jefferson LS
The Journal of nutrition 2015 Nov;145(11):2496-502
The Journal of nutrition 2015 Nov;145(11):2496-502
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.
Kim H, An S, Ro SH, Teixeira F, Park GJ, Kim C, Cho CS, Kim JS, Jakob U, Lee JH, Cho US
Nature communications 2015 Nov 27;6:10025
Nature communications 2015 Nov 27;6:10025
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
Ye J, Palm W, Peng M, King B, Lindsten T, Li MO, Koumenis C, Thompson CB
Genes & development 2015 Nov 15;29(22):2331-6
Genes & development 2015 Nov 15;29(22):2331-6
Sestrin2-AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity.
Seo K, Ki SH, Shin SM
Cellular signalling 2015 Jul;27(7):1533-43
Cellular signalling 2015 Jul;27(7):1533-43
Role of sestrin2 in the regulation of proinflammatory signaling in macrophages.
Yang JH, Kim KM, Kim MG, Seo KH, Han JY, Ka SO, Park BH, Shin SM, Ku SK, Cho IJ, Ki SH
Free radical biology & medicine 2015 Jan;78:156-67
Free radical biology & medicine 2015 Jan;78:156-67
Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.
Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Feb;29(2):408-17
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Feb;29(2):408-17
Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.
Yamani L, Li B, Larose L
Cellular signalling 2015 Dec;27(12):2555-67
Cellular signalling 2015 Dec;27(12):2555-67
The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation.
Han JY, Cho SS, Yang JH, Kim KM, Jang CH, Park DE, Bang JS, Jung YS, Ki SH
Toxicology and applied pharmacology 2015 Aug 15;287(1):77-85
Toxicology and applied pharmacology 2015 Aug 15;287(1):77-85
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Tao R, Xiong X, Liangpunsakul S, Dong XC
Diabetes 2015 Apr;64(4):1211-23
Diabetes 2015 Apr;64(4):1211-23
Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.
Kim MG, Yang JH, Kim KM, Jang CH, Jung JY, Cho IJ, Shin SM, Ki SH
Toxicological sciences : an official journal of the Society of Toxicology 2015 Apr;144(2):425-35
Toxicological sciences : an official journal of the Society of Toxicology 2015 Apr;144(2):425-35
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, Schnütgen F, Scheibe S, Seimetz M, Jaksch P, Hyman A, Weissmann N, von Melchner H
The Journal of biological chemistry 2015 Apr 10;290(15):9738-52
The Journal of biological chemistry 2015 Apr 10;290(15):9738-52
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
Ro SH, Semple IA, Park H, Park H, Park HW, Kim M, Kim JS, Lee JH
The FEBS journal 2014 Sep;281(17):3816-27
The FEBS journal 2014 Sep;281(17):3816-27
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
Peng M, Yin N, Li MO
Cell 2014 Sep 25;159(1):122-133
Cell 2014 Sep 25;159(1):122-133
Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.
Hamatani H, Hiromura K, Sakairi T, Takahashi S, Watanabe M, Maeshima A, Ohse T, Pippin JW, Shankland SJ, Nojima Y
American journal of physiology. Renal physiology 2014 Sep 15;307(6):F708-17
American journal of physiology. Renal physiology 2014 Sep 15;307(6):F708-17
Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.
Yang Y, Cuevas S, Yang S, Villar VA, Escano C, Asico L, Yu P, Jiang X, Weinman EJ, Armando I, Jose PA
Hypertension (Dallas, Tex. : 1979) 2014 Oct;64(4):825-32
Hypertension (Dallas, Tex. : 1979) 2014 Oct;64(4):825-32
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV
Cell reports 2014 Nov 20;9(4):1281-91
Cell reports 2014 Nov 20;9(4):1281-91
Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.
Ro SH, Nam M, Jang I, Park HW, Park H, Semple IA, Kim M, Kim JS, Park H, Einat P, Damari G, Golikov M, Feinstein E, Lee JH
Proceedings of the National Academy of Sciences of the United States of America 2014 May 27;111(21):7849-54
Proceedings of the National Academy of Sciences of the United States of America 2014 May 27;111(21):7849-54
Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.
Chen YS, Chen SD, Wu CL, Huang SS, Yang DI
Experimental neurology 2014 Mar;253:63-71
Experimental neurology 2014 Mar;253:63-71
Hepatoprotective role of Sestrin2 against chronic ER stress.
Park HW, Park H, Ro SH, Jang I, Semple IA, Kim DN, Kim M, Nam M, Zhang D, Yin L, Lee JH
Nature communications 2014 Jun 20;5:4233
Nature communications 2014 Jun 20;5:4233
p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.
Cam M, Bid HK, Xiao L, Zambetti GP, Houghton PJ, Cam H
The Journal of biological chemistry 2014 Feb 14;289(7):4083-94
The Journal of biological chemistry 2014 Feb 14;289(7):4083-94
Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.
Solhaug A, Torgersen ML, Holme JA, Lagadic-Gossmann D, Eriksen GS
Toxicology 2014 Dec 4;326:119-29
Toxicology 2014 Dec 4;326:119-29
Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.
Zhao B, Shah P, Budanov AV, Qiang L, Ming M, Aplin A, Sims DM, He YY
The Journal of biological chemistry 2014 Dec 26;289(52):35806-14
The Journal of biological chemistry 2014 Dec 26;289(52):35806-14
Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.
Kim GT, Lee SH, Kim JI, Kim YM
International journal of molecular medicine 2014 Apr;33(4):863-9
International journal of molecular medicine 2014 Apr;33(4):863-9
Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.
Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC
PloS one 2013;8(11):e78780
PloS one 2013;8(11):e78780
The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.
Buitrago-Molina LE, Marhenke S, Longerich T, Sharma AD, Boukouris AE, Geffers R, Guigas B, Manns MP, Vogel A
Hepatology (Baltimore, Md.) 2013 Sep;58(3):1143-52
Hepatology (Baltimore, Md.) 2013 Sep;58(3):1143-52
Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.
Kim GT, Lee SH, Kim YM
Journal of cancer prevention 2013 Sep;18(3):264-70
Journal of cancer prevention 2013 Sep;18(3):264-70
The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.
Forsberg K, Wuttke A, Quadrato G, Chumakov PM, Wizenmann A, Di Giovanni S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Sep 4;33(36):14318-30
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Sep 4;33(36):14318-30
Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD.
Heidler J, Fysikopoulos A, Wempe F, Seimetz M, Bangsow T, Tomasovic A, Veit F, Scheibe S, Pichl A, Weisel F, Lloyd KC, Jaksch P, Klepetko W, Weissmann N, von Melchner H
Disease models & mechanisms 2013 Nov;6(6):1378-87
Disease models & mechanisms 2013 Nov;6(6):1378-87
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Bae SH, Sung SH, Oh SY, Lim JM, Lee SK, Park YN, Lee HE, Kang D, Rhee SG
Cell metabolism 2013 Jan 8;17(1):73-84
Cell metabolism 2013 Jan 8;17(1):73-84
Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.
Kallenborn-Gerhardt W, Lu R, Syhr KM, Heidler J, von Melchner H, Geisslinger G, Bangsow T, Schmidtko A
Antioxidants & redox signaling 2013 Dec 10;19(17):2013-23
Antioxidants & redox signaling 2013 Dec 10;19(17):2013-23
Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.
Jin SH, Yang JH, Shin BY, Seo K, Shin SM, Cho IJ, Ki SH
Toxicology and applied pharmacology 2013 Aug 15;271(1):95-105
Toxicology and applied pharmacology 2013 Aug 15;271(1):95-105
Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.
Ben-Sahra I, Dirat B, Laurent K, Puissant A, Auberger P, Budanov A, Tanti JF, Bost F
Cell death and differentiation 2013 Apr;20(4):611-9
Cell death and differentiation 2013 Apr;20(4):611-9
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
Sanli T, Linher-Melville K, Tsakiridis T, Singh G
PloS one 2012;7(2):e32035
PloS one 2012;7(2):e32035
Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.
Soontornniyomkij V, Soontornniyomkij B, Moore DJ, Gouaux B, Masliah E, Tung S, Vinters HV, Grant I, Achim CL
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Sep;7(3):579-90
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Sep;7(3):579-90
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M
Cell metabolism 2012 Sep 5;16(3):311-21
Cell metabolism 2012 Sep 5;16(3):311-21
Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.
Caporali S, Alvino E, Levati L, Esposito AI, Ciomei M, Brasca MG, Del Bufalo D, Desideri M, Bonmassar E, Pfeffer U, D'Atri S
Biochemical pharmacology 2012 Sep 1;84(5):598-611
Biochemical pharmacology 2012 Sep 1;84(5):598-611
Mechanisms involved in alternariol-induced cell cycle arrest.
Solhaug A, Vines LL, Ivanova L, Spilsberg B, Holme JA, Pestka J, Collins A, Eriksen GS
Mutation research 2012 Oct-Nov;738-739:1-11
Mutation research 2012 Oct-Nov;738-739:1-11
Highly reactive meso-like positions of dipyrihexaphyrin.
Setsune J, Yamato K
Chemical communications (Cambridge, England) 2012 May 11;48(37):4447-9
Chemical communications (Cambridge, England) 2012 May 11;48(37):4447-9
Nrf2-ARE pathway regulates induction of Sestrin-2 expression.
Shin BY, Jin SH, Cho IJ, Ki SH
Free radical biology & medicine 2012 Aug 15;53(4):834-41
Free radical biology & medicine 2012 Aug 15;53(4):834-41
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Wempe F, De-Zolt S, Koli K, Bangsow T, Parajuli N, Dumitrascu R, Sterner-Kock A, Weissmann N, Keski-Oja J, von Melchner H
Disease models & mechanisms 2010 Mar-Apr;3(3-4):246-53
Disease models & mechanisms 2010 Mar-Apr;3(3-4):246-53
Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.
Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC
American journal of physiology. Endocrinology and metabolism 2010 Jun;298(6):E1283-94
American journal of physiology. Endocrinology and metabolism 2010 Jun;298(6):E1283-94
Role of sestrin2 in peroxide signaling in macrophages.
Essler S, Dehne N, Brüne B
FEBS letters 2009 Nov 3;583(21):3531-5
FEBS letters 2009 Nov 3;583(21):3531-5
Artemis is a negative regulator of p53 in response to oxidative stress.
Zhang X, Zhu Y, Geng L, Wang H, Legerski RJ
Oncogene 2009 Jun 4;28(22):2196-204
Oncogene 2009 Jun 4;28(22):2196-204
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.
Woo HA, Bae SH, Park S, Rhee SG
Antioxidants & redox signaling 2009 Apr;11(4):739-45
Antioxidants & redox signaling 2009 Apr;11(4):739-45
Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.
Doonan F, Wallace DM, O'Driscoll C, Cotter TG
Journal of neurochemistry 2009 Apr;109(2):631-43
Journal of neurochemistry 2009 Apr;109(2):631-43
A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell.
O'Connor JC, Wallace DM, O'Brien CJ, Cotter TG
Investigative ophthalmology & visual science 2008 Oct;49(10):4237-44
Investigative ophthalmology & visual science 2008 Oct;49(10):4237-44
Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure.
Ding B, Chi SG, Kim SH, Kang S, Cho JH, Kim DS, Cho NH
Journal of cell science 2007 Jul 1;120(Pt 13):2284-94
Journal of cell science 2007 Jul 1;120(Pt 13):2284-94
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10795-1-AP(Sestrin2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using SESN2 antibody 10795-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-Sestrin2 (IP:10795-1-AP, 3ug; Detection:10795-1-AP 1:1000) with K-562 cells lysate 4000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10795-1-AP(Sestrin2 antibody) at dilution of 1:100 (under 25x lens)
- Sample type
- tissue
