11416-1-AP

antibody from Proteintech Group

Targeting: COX7A2L COX7AR, COX7RP, EB1, SIG81

Provider product page for 11416-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [13]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 11416-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11416-1-AP, RRID:AB_2245402
Product name: COX7A2L antibody
Antibody type: Polyclonal
Description: KD/KO validated COX7A2L antibody (Cat. #11416-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

COX7A2L protein structure - 11416-1-AP shown in red.

Submitted references SILAC-based complexome profiling dissects the structural organization of the human respiratory supercomplexes in SCAFI^KO cells.

Fernández-Vizarra E, López-Calcerrada S, Formosa LE, Pérez-Pérez R, Ding S, Fearnley IM, Arenas J, Martín MA, Zeviani M, Ryan MT, Ugalde C
Biochimica et biophysica acta. Bioenergetics 2021 Jul 1;1862(7):148414

Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer.

Hollinshead KER, Parker SJ, Eapen VV, Encarnacion-Rosado J, Sohn A, Oncu T, Cammer M, Mancias JD, Kimmelman AC
Cell reports 2020 Oct 6;33(1):108231

Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis.

Timón-Gómez A, Garlich J, Stuart RA, Ugalde C, Barrientos A
Cell reports 2020 May 5;31(5):107607

Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes.

Lobo-Jarne T, Pérez-Pérez R, Fontanesi F, Timón-Gómez A, Wittig I, Peñas A, Serrano-Lorenzo P, García-Consuegra I, Arenas J, Martín MA, Barrientos A, Ugalde C
The EMBO journal 2020 Jul 15;39(14):e103912

Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics.

Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A
Cell reports 2018 Nov 13;25(7):1786-1799.e4

Cardioprotective strategies preserve the stability of respiratory chain supercomplexes and reduce oxidative stress in reperfused ischemic hearts.

Ramírez-Camacho I, Correa F, El Hafidi M, Silva-Palacios A, Ostolga-Chavarría M, Esparza-Perusquía M, Olvera-Sánchez S, Flores-Herrera O, Zazueta C
Free radical biology & medicine 2018 Dec;129:407-417

Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice.

Shiba S, Ikeda K, Horie-Inoue K, Nakayama A, Tanaka T, Inoue S
Scientific reports 2017 Aug 8;7(1):7606

COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation.

Pérez-Pérez R, Lobo-Jarne T, Milenkovic D, Mourier A, Bratic A, García-Bartolomé A, Fernández-Vizarra E, Cadenas S, Delmiro A, García-Consuegra I, Arenas J, Martín MA, Larsson NG, Ugalde C
Cell reports 2016 Aug 30;16(9):2387-98

COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy.

Zhang K, Wang G, Zhang X, Hüttemann PP, Qiu Y, Liu J, Mitchell A, Lee I, Zhang C, Lee JS, Pecina P, Wu G, Yang ZQ, Hüttemann M, Grossman LI
Scientific reports 2016 Aug 23;6:31742

Supercomplex assembly determines electron flux in the mitochondrial electron transport chain.

Lapuente-Brun E, Moreno-Loshuertos R, Acín-Pérez R, Latorre-Pellicer A, Colás C, Balsa E, Perales-Clemente E, Quirós PM, Calvo E, Rodríguez-Hernández MA, Navas P, Cruz R, Carracedo Á, López-Otín C, Pérez-Martos A, Fernández-Silva P, Fernández-Vizarra E, Enríquez JA
Science (New York, N.Y.) 2013 Jun 28;340(6140):1567-70

Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria.

Aichler M, Elsner M, Ludyga N, Feuchtinger A, Zangen V, Maier SK, Balluff B, Schöne C, Hierber L, Braselmann H, Meding S, Rauser S, Zischka H, Aubele M, Schmitt M, Feith M, Hauck SM, Ueffing M, Langer R, Kuster B, Zitzelsberger H, Höfler H, Walch AK
The Journal of pathology 2013 Aug;230(4):410-9

MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma.

Elsner M, Rauser S, Maier S, Schöne C, Balluff B, Meding S, Jung G, Nipp M, Sarioglu H, Maccarrone G, Aichler M, Feuchtinger A, Langer R, Jütting U, Feith M, Küster B, Ueffing M, Zitzelsberger H, Höfler H, Walch A
Journal of proteomics 2012 Aug 3;75(15):4693-704

Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain.

Li N, Bates DJ, An J, Terry DA, Wang E
Neurobiology of aging 2011 May;32(5):944-55

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 11416-1-AP( COX7A2L Antibody) at dilution of 1:600
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The COX7A2L antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COX7A2L. This antibody recognizes human,mouse,rat antigen. The COX7A2L antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11416-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human ovary tumor using 11416-1-AP(COX7A2L antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue