PLA2G15

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]

Description

Phospholipase A2 group XV

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (68245304 - 68261058)

Ensembl ID

ENSG00000103066  (ver. 103.38)

Orthologs

Mouse Pla2g15: ENSMUSG00000031903

UniProt

Q8NCC3

neXtProt

NX_Q8NCC3

Human splice variants
Mouse splice variants

Protein structure