SLC25A5

This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

Description

Solute carrier family 25 member 5

Tissue specificity

Low tissue specificity

Subcell location

Mitochondria

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

X (119468422 - 119471396)

Ensembl ID

ENSG00000005022  (ver. 103.38)

Orthologs

Mouse Slc25a5: ENSMUSG00000016319

UniProt

P05141

neXtProt

NX_P05141

Human splice variants
Mouse splice variants

Protein structure