CABT-B1234

antibody from Creative Diagnostics

Targeting: WAPL FOE, KIAA0261, WAPAL

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

CABT-B1234

Provider

Creative Diagnostics

Product name

Anti-WAPL monoclonal antibody, clone 2D8-C2

Antibody type

Monoclonal

Description

Wings apart-like protein homolog (also known as Friend of Epstein-Barr virus nuclear protein 2) is a nuclear protein encoded by the WAPL (WAPAL) gene in human. Wapl functions as a negative regulator of cohesinÿchromosome association and facilitates the progression of mitosis both during interphase and prophase. In interphase, Wapl destabilizes cohesinÿchromosome interaction and thereby reduces the extent of cohesin-mediated chromosome looping. In prophase, mitotic kinases phosphorylate cohesin and its regulators. Wapl then triggers the release of phosphorylated cohesin from sister chromatids, allowing sister chromosome decatenation by topoisomerase II (Topo II).

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG