ABIN372660

antibody from antibodies-online

Targeting: IFNAR1 IFNAR, IFRC

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN372660

Provider

antibodies-online

Product name

anti-Interferon (Alpha, beta and Omega) Receptor 1 (IFNAR1) (pSer539), (pSer535) antibody

Antibody type

Polyclonal

Antigen

Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser535,539 of Human IFNAR1.

Description

Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Reactivity

Human, Mouse, Rat, Bovine, Canine, Sheep

Host

Rabbit

Epitope

pSer539,pSer535

Isotype

IgG

Vial size

0.1 mL

Storage

Store the antibody undiluted (in aliquots) at-20°C.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor.

Bhattacharya S, HuangFu WC, Liu J, Veeranki S, Baker DP, Koumenis C, Diehl JA, Fuchs SY
The Journal of biological chemistry 2010 Jan 22;285(4):2318-25

---

SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.

Kumar KG, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs SY
The EMBO journal 2003 Oct 15;22(20):5480-90

---

Cancer immunotherapy: the interferon-alpha experience.

Kirkwood J
Seminars in oncology 2002 Jun;29(3 Suppl 7):18-26

---

Interferons alpha and beta as immune regulators--a new look.

Biron CA
Immunity 2001 Jun;14(6):661-4