APR02328G

antibody from Leading Biology

Targeting: SEM1 C7orf76, DSS1, ECD, FLJ42280, SHFD1, Shfdg1, SHFM1, SHSF1

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR02328G

Provider

Leading Biology

Product name

SHSF1 / SHFM1 Antibody (aa57-70)

Antibody type

Polyclonal

Description

Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription- associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.

Reactivity

Human

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.