NB300-232

Pan H, Jiang N, Sun S, Jiang H, Xu J, Jiang X, Gao Q, Li L, Wu H, Zheng H, Qi Q, Li T, Zhang M, Zhang L, Wan X, Lin X, Wong J, Shi Q, Li R
Cell death & disease 2020 Feb 21;11(2):142

BRUCE preserves genomic stability in the male germline of mice.

Che L, Alavattam KG, Stambrook PJ, Namekawa SH, Du C
Cell death and differentiation 2020 Aug;27(8):2402-2416

Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes.

Harpelunde Poulsen K, Nielsen JE, Frederiksen H, Melau C, Juul Hare K, Langhoff Thuesen L, Perlman S, Lundvall L, Mitchell RT, Juul A, Rajpert-De Meyts E, Jørgensen A
Human reproduction (Oxford, England) 2019 Nov 1;34(11):2228-2243

Chemical Contaminants from Plastics in the Animal Environment.

Gorence GJ, Pulcastro HC, Lawson CA, Gerona RR, Friesen M, Horan TS, Gieske MC, Sartain CV, Hunt PA
Journal of the American Association for Laboratory Animal Science : JAALAS 2019 Mar 1;58(2):190-196

The testis-specifically expressed Dpep3 is not essential for male fertility in mice.

Xie Y, Khan R, Wahab F, Hussain HMJ, Ali A, Ma H, Jiang H, Xu J, Zaman Q, Khan M, Jiang X, Shi Q
Gene 2019 Aug 30;711:143925

Meiotic Synapsis and Gene Expression Altered by a Balanced Y-Autosome Reciprocal Translocation in an Azoospermic Pig.

Mary N, Villagómez DAF, Revay T, Rezaei S, Donaldson B, Pinton A, King WA
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2018 Sep 5;12(5)

Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis.

Jørgensen A, Macdonald J, Nielsen JE, Kilcoyne KR, Perlman S, Lundvall L, Langhoff Thuesen L, Juul Hare K, Frederiksen H, Andersson AM, Skakkebæk NE, Juul A, Sharpe RM, Rajpert-De Meyts E, Mitchell RT
Cell reports 2018 Nov 13;25(7):1924-1937.e4

Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice.

Mu X, Wen J, Chen Q, Wang Z, Wang Y, Guo M, Yang Y, Xu J, Wei Z, Xia G, Yang M, Wang C
Biology open 2018 Nov 12;7(11)

Nicotine exposure impairs germ cell development in human fetal ovaries cultured in vitro.

Cheng SF, Qin XS, Han ZL, Sun XF, Feng YN, Yang F, Ge W, Li L, Zhao Y, De Felici M, Zou SH, Zhou Y, Shen W
Aging 2018 Jul 12;10(7):1556-1574

Exposure to Zinc oxide nanoparticles during pregnancy induces oocyte DNA damage and affects ovarian reserve of mouse offspring.

Zhai QY, Ge W, Wang JJ, Sun XF, Ma JM, Liu JC, Zhao Y, Feng YZ, Dyce PW, De Felici M, Shen W
Aging 2018 Aug 28;10(8):2170-2189

Effect of low-dose zearalenone exposure on reproductive capacity of male mice.

Pang J, Zhou Q, Sun X, Li L, Zhou B, Zeng F, Zhao Y, Shen W, Sun Z
Toxicology and applied pharmacology 2017 Oct 15;333:60-67

In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells.

Jung D, Xiong J, Ye M, Qin X, Li L, Cheng S, Luo M, Peng J, Dong J, Tang F, Shen W, Matzuk MM, Kee K
Nature communications 2017 Jun 12;8:15680

XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development.

Vallot C, Patrat C, Collier AJ, Huret C, Casanova M, Liyakat Ali TM, Tosolini M, Frydman N, Heard E, Rugg-Gunn PJ, Rougeulle C
Cell stem cell 2017 Jan 5;20(1):102-111

Characterization of the testicular regeneration potential in premature cockerels.

Cheng PL, Wu HR, Li CY, Chen CF, Cheng HC
The Journal of reproduction and development 2017 Dec 15;63(6):563-570

A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency.

Fouquet B, Pawlikowska P, Caburet S, Guigon C, Mäkinen M, Tanner L, Hietala M, Urbanska K, Bellutti L, Legois B, Bessieres B, Gougeon A, Benachi A, Livera G, Rosselli F, Veitia RA, Misrahi M
eLife 2017 Dec 12;6

Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro.

Liu JC, Lai FN, Li L, Sun XF, Cheng SF, Ge W, Wang YF, Li L, Zhang XF, De Felici M, Dyce PW, Shen W
Cell death & disease 2017 Aug 3;8(8):e2966

The impact of Zearalenone on the meiotic progression and primordial follicle assembly during early oogenesis.

Liu KH, Sun XF, Feng YZ, Cheng SF, Li B, Li YP, Shen W, Li L
Toxicology and applied pharmacology 2017 Aug 15;329:9-17

Trim27 interacts with Slx2, is associated with meiotic processes during spermatogenesis.

Zhuang XJ, Tang WH, Feng X, Liu CY, Zhu JL, Yan J, Liu DF, Liu P, Qiao J
Cell cycle (Georgetown, Tex.) 2016 Oct;15(19):2576-2584

Fasciola hepatica: a light and electron microscope study of the ovary and of the development of oocytes within eggs in the uterus provides an insight into reproductive strategy.

Hanna RE, Moffett D, Forster FI, Trudgett AG, Brennan GP, Fairweather I
Veterinary parasitology 2016 May 15;221:93-103

Overexpression of Anti-Müllerian Hormone Disrupts Gonadal Sex Differentiation, Blocks Sex Hormone Synthesis, and Supports Cell Autonomous Sex Development in the Chicken.

Lambeth LS, Morris K, Ayers KL, Wise TG, O'Neil T, Wilson S, Cao Y, Sinclair AH, Cutting AD, Doran TJ, Smith CA
Endocrinology 2016 Mar;157(3):1258-75

On the development of extragonadal and gonadal human germ cells.

Heeren AM, He N, de Souza AF, Goercharn-Ramlal A, van Iperen L, Roost MS, Gomes Fernandes MM, van der Westerlaken LA, Chuva de Sousa Lopes SM
Biology open 2016 Feb 1;5(2):185-94

Polycomb repressive complex 1 (PRC1) regulates meiotic initiation of ovarian germ cells in chick embryos.

Tang X, Xu S, Li R, Zhang H, Chen Q, Wu W, Liu H
Molecular and cellular endocrinology 2016 Dec 5;437:171-182

Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis.

Cadalbert LC, Ghaffar FN, Stevenson D, Bryson S, Vaz FM, Gottlieb E, Strathdee D
PloS one 2015;10(6):e0131066

Differentiation of early germ cells from human skin-derived stem cells without exogenous gene integration.

Ge W, Ma HG, Cheng SF, Sun YC, Sun LL, Sun XF, Li L, Dyce P, Li J, Shi QH, Shen W
Scientific reports 2015 Sep 8;5:13822

Meiotic wave adds extra asymmetry to the development of female chicken gonads.

de Melo Bernardo A, Heeren AM, van Iperen L, Fernandes MG, He N, Anjie S, Noce T, Ramos ES, de Sousa Lopes SM
Molecular reproduction and development 2015 Oct;82(10):774-86

Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse.

Liang GJ, Zhang XF, Wang JJ, Sun YC, Sun XF, Cheng SF, Li L, De Felici M, Shen W
Stem cells and development 2015 Oct 15;24(20):2455-65

The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse.

Link J, Jahn D, Schmitt J, Göb E, Baar J, Ortega S, Benavente R, Alsheimer M
PLoS genetics 2013;9(1):e1003261

Cytological studies of human meiosis: sex-specific differences in recombination originate at, or prior to, establishment of double-strand breaks.

Gruhn JR, Rubio C, Broman KW, Hunt PA, Hassold T
PloS one 2013;8(12):e85075

Regulation of the DNA damage response on male meiotic sex chromosomes.

Lu LY, Xiong Y, Kuang H, Korakavi G, Yu X
Nature communications 2013;4:2105

Germline mosaicism does not explain the maternal age effect on trisomy.

Rowsey R, Kashevarova A, Murdoch B, Dickenson C, Woodruff T, Cheng E, Hunt P, Hassold T
American journal of medical genetics. Part A 2013 Oct;161A(10):2495-503

No evidence for neo-oogenesis may link to ovarian senescence in adult monkey.

Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L
Stem cells (Dayton, Ohio) 2013 Nov;31(11):2538-50

Dysregulation of the mitosis-meiosis switch in testicular carcinoma in situ.

Jørgensen A, Nielsen JE, Almstrup K, Toft BG, Petersen BL, Rajpert-De Meyts E
The Journal of pathology 2013 Mar;229(4):588-98

Deleted in azoospermia-like enhances in vitro derived porcine germ cell formation and meiosis.

Park BW, Shen W, Linher-Melville K, Li J
Stem cells and development 2013 Mar 15;22(6):939-50

The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation.

Gkountela S, Li Z, Vincent JJ, Zhang KX, Chen A, Pellegrini M, Clark AT
Nature cell biology 2013 Jan;15(1):113-22

Recovery of functional oocytes from cultured premeiotic germ cells after kidney capsule transplantation.

Chen B, Zhang L, Tang J, Feng X, Feng Y, Liang G, Wang L, Feng Y, Li L, De Felici M, Shi Q, Shen W
Stem cells and development 2013 Feb 15;22(4):567-80

In vitro production of haploid cells after coculture of CD49f+ with Sertoli cells from testicular sperm extraction in nonobstructive azoospermic patients.

Riboldi M, Rubio C, Pellicer A, Gil-Salom M, Simón C
Fertility and sterility 2012 Sep;98(3):580-590.e4

Analysis of meiosis regulators in human gonads: a sexually dimorphic spatio-temporal expression pattern suggests involvement of DMRT1 in meiotic entry.

Jørgensen A, Nielsen JE, Blomberg Jensen M, Græm N, Rajpert-De Meyts E
Molecular human reproduction 2012 Nov;18(11):523-34

Molecular signatures to define spermatogenic cells in common marmoset (Callithrix jacchus).

Lin ZY, Imamura M, Sano C, Nakajima R, Suzuki T, Yamadera R, Takehara Y, Okano HJ, Sasaki E, Okano H
Reproduction (Cambridge, England) 2012 May;143(5):597-609

Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro.

Medrano JV, Ramathal C, Nguyen HN, Simon C, Reijo Pera RA
Stem cells (Dayton, Ohio) 2012 Mar;30(3):441-51

HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes.

Kogo H, Tsutsumi M, Ohye T, Inagaki H, Abe T, Kurahashi H
Genes to cells : devoted to molecular & cellular mechanisms 2012 Jun;17(6):439-54

Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women.

White YA, Woods DC, Takai Y, Ishihara O, Seki H, Tilly JL
Nature medicine 2012 Feb 26;18(3):413-21

A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.

Schramm S, Fraune J, Naumann R, Hernandez-Hernandez A, Höög C, Cooke HJ, Alsheimer M, Benavente R
PLoS genetics 2011 May;7(5):e1002088

Analyzing mammalian female meiosis.

Susiarjo M, Rubio C, Hunt P
Methods in molecular biology (Clifton, N.J.) 2009;558:339-54

Vascular endothelial growth factor regulates germ cell survival during establishment of spermatogenesis in the bovine testis.

Caires KC, de Avila J, McLean DJ
Reproduction (Cambridge, England) 2009 Oct;138(4):667-77

Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men.

Brown PW, Hwang K, Schlegel PN, Morris PL
Human reproduction (Oxford, England) 2008 Dec;23(12):2850-7

Germline stem cells and neo-oogenesis in the adult human ovary.

Liu Y, Wu C, Lyu Q, Yang D, Albertini DF, Keefe DL, Liu L
Developmental biology 2007 Jun 1;306(1):112-20

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: SCP3/SYCP3 Antibody [NB300-232] - SCP3 Antibody [NB300-232] - Analysis of SCP3 in mouse testis protein.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: SCP3/SYCP3 Antibody [NB300-232] - IHC-P analysis of formalin fixed paraffin embedded tissue section of mouse testes using SCP3 antibody at 1:200 dilution. Specific staining may be seen in the spermatogonial cells and the primary spermatocytes.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: SCP3/SYCP3 Antibody [NB300-232] - IHC analysis of a formalin fixed and paraffin embedded tissue section of Mouse testis using SCP3 antibody at 1:1000 dilution. The signal was detected using HRP-DAB detection method and the nuclei were counterstained with hematoxylin. The antibody generated a specific signal of SCP3 in the spermatogonial cells and the spermatocytes. The signal was strongest in the nuclei of spermatogonial cells.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: SCP3/SYCP3 Antibody [NB300-232] - Analysis of SCP3 in human testis using DAB with hematoxylin counterstain.