Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
TCIRG1
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3a3, Atp6i, ATP6N1C, ATP6V0A3, OC-116, OC116, TIRC7
This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017]
Top validated antibodies |
|||||
| Proteintech Group |  12649-1-AP |
7 references | Polyclonal |
WB
EL
ICC
|
|
| Invitrogen Antibodies | PA5-90425 |
1 references | Polyclonal |
WB
ICC
IHC
|
|
| Antibodies.com | A91446 |
1 references | Polyclonal |
WB
ICC
IHC
|
|
| Novus Biologicals | 43480002 |
2 references | Polyclonal |
WB
EL
|
|
| antibodies-online | ABIN1450004 |
4 references | Polyclonal |
WB
EL
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider