WFDC1

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Description

WAP four-disulfide core domain 1

Tissue specificity

Tissue enhanced (placenta, seminal vesicle)

Predicted location

Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

16 (84294846 - 84329844)

Ensembl ID

ENSG00000103175  (ver. 103.38)

Orthologs

Mouse Wfdc1: ENSMUSG00000023336

UniProt

Q9HC57

neXtProt

NX_Q9HC57

Human splice variants
Mouse splice variants

Protein structure