GAL

This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]

Description

Galanin and GMAP prepropeptide

Tissue specificity

Group enriched (brain, pituitary gland)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Secreted to blood

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (68683779 - 68691175)

Ensembl ID

ENSG00000069482  (ver. 103.38)

Orthologs

Mouse Gal: ENSMUSG00000024907

UniProt

P22466

neXtProt

NX_P22466

Human splice variants
Mouse splice variants

Protein structure