Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS6312 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL18BP polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IL18BP.
- Description
- IL-18 (also referred to as IL-1ÎÛ) has been shown to augment the secretion of IFN-ÎÛ from T lymphocytes and to increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1Ï« and IL-ÉÇ, respectively, over the twelve ÉÇ-strands of the ÉÇ-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1ÉÇ pro-domain, which must be cleaved by the serine protease ICE for optimal secretion and biological activity. IL-18, which was originally described as IGIF (IFN-ÎÛ-inducing factor), IL-18 is induced in mouse liver subsequent to challenge with lipopolysaccharide (LPS). IL-18 binding protein (IL-18BP) functions as an inhibitor of the early Th1 response by binding to IL-18 and inhibiting IFN-ÎÛ production. IL-18BP is a member of the immunoglobulin superfamily and shares some homology to IL-1RII.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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