BS6312

antibody from Bioworld Technology, Inc
Targeting: IL18BP IL18BPa
Provider product page for BS6312
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6312 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL18BP polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human IL18BP.
Description
IL-18 (also referred to as IL-1ÎÛ) has been shown to augment the secretion of IFN-ÎÛ from T lymphocytes and to increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1Ï« and IL-ÉÇ, respectively, over the twelve ÉÇ-strands of the ÉÇ-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1ÉÇ pro-domain, which must be cleaved by the serine protease ICE for optimal secretion and biological activity. IL-18, which was originally described as IGIF (IFN-ÎÛ-inducing factor), IL-18 is induced in mouse liver subsequent to challenge with lipopolysaccharide (LPS). IL-18 binding protein (IL-18BP) functions as an inhibitor of the early Th1 response by binding to IL-18 and inhibiting IFN-ÎÛ production. IL-18BP is a member of the immunoglobulin superfamily and shares some homology to IL-1RII.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL18BP protein structure - BS6312 shown in red.