BS60155

antibody from Bioworld Technology, Inc
Targeting: FOLR3 FR-G, FRĪ³
Provider product page for BS60155

Antibody data

Product number
BS60155 - Provider product page
Provider
Bioworld Technology, Inc
Product name
FOLR3 polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human FOLR3.
Description
Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell. The folate receptors consist of five members, Ï«, ÉÇ, ÎÛ, ÎÛ' (which is produced by alternative splicing) and Ñ´. ÉÇ-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin. ÎÛ-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of Ñ´-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The Ï« isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
FOLR3 protein structure - BS60155 shown in red.