Tissue expression
Cell line expression
Protein structure
CLPB
Caseinolytic mitochondrial matrix peptidase chaperone subunit BANKCLB, FLJ13152, HSP78, SKD3
This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Top validated antibodies |
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NSJ Bioreagents | RQ5877 | Polyclonal |
WB
EL
ICC
IHC
FC
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Boster Biological Technology | A02912-2 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Biorbyt | orb654414 | Polyclonal |
WB
EL
ICC
IHC
FC
|
||
Proteintech Group | 15743-1-AP | 1 references | Polyclonal |
WB
EL
IHC
|
|
Atlas Antibodies | HPA039005 | Polyclonal |
WB
IHC |
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Supportive data in Antibodypedia
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider