Tissue expression
Cell line expression
Protein structure
UBE3B
Ubiquitin protein ligase E3BThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
Top validated antibodies |
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Invitrogen Antibodies | PA5-59390 | 1 references | Polyclonal |
ICC
IHC
OA
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Affinity Biosciences | AF9221 | Polyclonal |
WB
EL
ICC
IHC |
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LSBio | LS-C801857 | Polyclonal |
WB
EL
ICC
IHC |
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Novus Biologicals | NBP1-92559 | 1 references | Polyclonal |
ICC
IHC |
|
antibodies-online | ABIN2500925 | Polyclonal |
WB
EL
ICC
IHC |
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