Antibody data
- Antibody Data
- Antigen structure
- References [36]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 11081-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11081-1-AP, RRID:AB_2213793
- Product name
- UCP2 antibody
- Antibody type
- Polyclonal
- Description
- UCP2 antibody (Cat. #11081-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ShenmaYizhi Decoction Improves the Mitochondrial Structure in the Brain and Ameliorates Cognitive Impairment in VCI Rats via the AMPK/UCP2 Signaling Pathway.
Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage.
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
High glucose induces apoptosis, glycogen accumulation and suppresses protein synthesis in muscle cells of olive flounder Paralichthys olivaceus.
Zinc-α2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice.
Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis.
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.
Far-infrared radiation prevents decline in β-cell mass and function in diabetic mice via the mitochondria-mediated Sirtuin1 pathway.
Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats.
Role and mechanism of FLNa and UCP2 in the development of cervical cancer.
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome.
Upregulation of UCP2 Expression Protects against LPS-Induced Oxidative Stress and Apoptosis in Cardiomyocytes.
Different impacts on brain function depending on the mode of delivery.
Insulin-like growth factor-1 directly mediates expression of mitochondrial uncoupling protein 3 via forkhead box O4.
G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats.
IGF-1 regulate the expression of uncoupling protein 2 via FOXO1.
Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice.
Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
Insulin alleviates mitochondrial oxidative stress involving upregulation of superoxide dismutase 2 and uncoupling protein 2 in septic acute kidney injury.
Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury.
UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap Alternation in the Developing Neocortex.
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
Mechanism of uncoupling protein 2‑mediated myocardial injury in hypothermic preserved rat hearts.
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.
Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.
Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis.
PI3K/Akt/uncoupling protein 2 signaling pathway may be involved in cell senescence and apoptosis induced by angiotensin II in human vascular endothelial cells.
Uncoupling protein 2 expression affects androgen synthesis in polycystic ovary syndrome.
Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.
Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.
Sun C, Liu M, Liu J, Zhang T, Zhang L, Li H, Luo Z
Neuropsychiatric disease and treatment 2021;17:1937-1951
Neuropsychiatric disease and treatment 2021;17:1937-1951
Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage.
Tu T, Yin S, Pang J, Zhang X, Zhang L, Zhang Y, Xie Y, Guo K, Chen L, Peng J, Jiang Y
Frontiers in aging neuroscience 2021;13:640215
Frontiers in aging neuroscience 2021;13:640215
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Yang M, Cui Y, Song J, Cui C, Wang L, Liang K, Wang C, Sha S, He Q, Hu H, Guo X, Zang N, Sun L, Chen L
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
High glucose induces apoptosis, glycogen accumulation and suppresses protein synthesis in muscle cells of olive flounder Paralichthys olivaceus.
Liu J, Pan M, Huang D, Wu J, Liu Y, Guo Y, Zhang W, Mai K
The British journal of nutrition 2021 Jul 14;:1-12
The British journal of nutrition 2021 Jul 14;:1-12
Zinc-α2-glycoprotein promotes skeletal muscle lipid metabolism in cold-stressed mice.
Fan G, Li Y, Ma F, Zhao R, Yang X
Endocrine journal 2021 Jan 28;68(1):53-62
Endocrine journal 2021 Jan 28;68(1):53-62
Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis.
Zheng X, Liu D
Life sciences 2021 Jan 15;265:118825
Life sciences 2021 Jan 15;265:118825
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542
The Journal of nutritional biochemistry 2021 Feb;88:108542
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
Zhang S, Feng Z, Gao W, Duan Y, Fan G, Geng X, Wu B, Li K, Liu K, Peng C
Frontiers in pharmacology 2020;11:544124
Frontiers in pharmacology 2020;11:544124
Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.
Liang KX, Kristiansen CK, Mostafavi S, Vatne GH, Zantingh GA, Kianian A, Tzoulis C, Høyland LE, Ziegler M, Perez RM, Furriol J, Zhang Z, Balafkan N, Hong Y, Siller R, Sullivan GJ, Bindoff LA
EMBO molecular medicine 2020 Oct 7;12(10):e12146
EMBO molecular medicine 2020 Oct 7;12(10):e12146
Far-infrared radiation prevents decline in β-cell mass and function in diabetic mice via the mitochondria-mediated Sirtuin1 pathway.
Hsu YH, Chen YC, Chen YW, Chiu TH, Kuo YT, Chen CH
Metabolism: clinical and experimental 2020 Mar;104:154143
Metabolism: clinical and experimental 2020 Mar;104:154143
Brain Overexpression of Uncoupling Protein-2 (UCP2) Delays Renal Damage and Stroke Occurrence in Stroke-Prone Spontaneously Hypertensive Rats.
Busceti CL, Cotugno M, Bianchi F, Forte M, Stanzione R, Marchitti S, Battaglia G, Nicoletti F, Fornai F, Rubattu S
International journal of molecular sciences 2020 Jun 16;21(12)
International journal of molecular sciences 2020 Jun 16;21(12)
Role and mechanism of FLNa and UCP2 in the development of cervical cancer.
Wang A, Liu L, Yuan M, Han S, You X, Zhang H, Lei F, Zhang Y
Oncology reports 2020 Dec;44(6):2656-2668
Oncology reports 2020 Dec;44(6):2656-2668
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, Wang J, Sun L
IUBMB life 2020 Aug;72(8):1659-1679
IUBMB life 2020 Aug;72(8):1659-1679
Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome.
Zhang H, Ma Y, Cao R, Wang G, Li S, Cao Y, Zhang H, Liu M, Liu G, Zhang J, Li S, Wang Y, Ma Y
Journal of cellular and molecular medicine 2020 Aug;24(15):8849-8861
Journal of cellular and molecular medicine 2020 Aug;24(15):8849-8861
Upregulation of UCP2 Expression Protects against LPS-Induced Oxidative Stress and Apoptosis in Cardiomyocytes.
Huang J, Peng W, Zheng Y, Hao H, Li S, Yao Y, Ding Y, Zhang J, Lyu J, Zeng Q
Oxidative medicine and cellular longevity 2019;2019:2758262
Oxidative medicine and cellular longevity 2019;2019:2758262
Different impacts on brain function depending on the mode of delivery.
Ikeda K, Onimaru H, Matsuura T, Kawakami K
Brain research 2019 Oct 1;1720:146289
Brain research 2019 Oct 1;1720:146289
Insulin-like growth factor-1 directly mediates expression of mitochondrial uncoupling protein 3 via forkhead box O4.
Watamoto Y, Futawaka K, Hayashi M, Matsushita M, Mitsutani M, Murakami K, Song Z, Koyama R, Fukuda Y, Nushida A, Nezu S, Kuwahara A, Kataoka K, Tagami T, Moriyama K
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2019 Jun - Aug;46-47:24-35
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2019 Jun - Aug;46-47:24-35
G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats.
Wang J, Yu R, Han QQ, Huang HJ, Wang YL, Li HY, Wang HM, Chen XR, Ma SL, Yu J
Behavioural brain research 2019 Feb 1;359:845-852
Behavioural brain research 2019 Feb 1;359:845-852
IGF-1 regulate the expression of uncoupling protein 2 via FOXO1.
Watamoto Y, Futawaka K, Hayashi M, Matsushita M, Mitsutani M, Song Z, Koyama R, Fukuda Y, Nushida A, Nezu S, Kuwahara A, Kataoka K, Tagami T, Moriyama K
Growth factors (Chur, Switzerland) 2019 Dec;37(5-6):247-256
Growth factors (Chur, Switzerland) 2019 Dec;37(5-6):247-256
Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice.
Lu B, Zhong J, Pan J, Yuan X, Ren M, Jiang L, Yang Y, Zhang G, Liu D, Zhang C
Journal of translational medicine 2019 Dec 17;17(1):422
Journal of translational medicine 2019 Dec 17;17(1):422
Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice.
Zhong H, Liu M, Ji Y, Ma M, Chen K, Liang T, Liu C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1885-1897
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(5):1885-1897
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis.
Rodríguez-Hidalgo M, Luna-Sánchez M, Hidalgo-Gutiérrez A, Barriocanal-Casado E, Mascaraque C, Acuña-Castroviejo D, Rivera M, Escames G, López LC
Scientific reports 2018 Sep 18;8(1):14013
Scientific reports 2018 Sep 18;8(1):14013
mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
Wang X, Sun B, Jiang Q, Wu R, Cai M, Yao Y, Liu Q, Shi H, Feng J, Wang Y
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
International journal of obesity (2005) 2018 Nov;42(11):1912-1924
Insulin alleviates mitochondrial oxidative stress involving upregulation of superoxide dismutase 2 and uncoupling protein 2 in septic acute kidney injury.
Chen GD, Zhang JL, Chen YT, Zhang JX, Wang T, Zeng QY
Experimental and therapeutic medicine 2018 Apr;15(4):3967-3975
Experimental and therapeutic medicine 2018 Apr;15(4):3967-3975
Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury.
Chen K, Xu Z, Liu Y, Wang Z, Li Y, Xu X, Chen C, Xia T, Liao Q, Yao Y, Zeng C, He D, Yang Y, Tan T, Yi J, Zhou J, Zhu H, Ma J, Zeng C
Science translational medicine 2017 Nov 29;9(418)
Science translational medicine 2017 Nov 29;9(418)
UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap Alternation in the Developing Neocortex.
Ji F, Shen T, Zou W, Jiao J
Stem cells (Dayton, Ohio) 2017 Jun;35(6):1479-1492
Stem cells (Dayton, Ohio) 2017 Jun;35(6):1479-1492
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, Feng M, Li X, Ye X
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Mechanism of uncoupling protein 2‑mediated myocardial injury in hypothermic preserved rat hearts.
Chen GG, Yan JB, Wang XM, Zheng MZ, Jiang JP, Zhou XM, Cai B, Shen YL
Molecular medicine reports 2016 Aug;14(2):1857-64
Molecular medicine reports 2016 Aug;14(2):1857-64
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
He K, Li X, Xiao Y, Yong Y, Zhang Z, Li S, Zhou T, Yang D, Gao P, Xin X
Food & function 2016 Aug 10;7(8):3505-15
Food & function 2016 Aug 10;7(8):3505-15
Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.
Xie X, Zhang J, Chen D, Pan H, Wu Z, Ge D, Yang G
Shock (Augusta, Ga.) 2015 May;43(5):490-6
Shock (Augusta, Ga.) 2015 May;43(5):490-6
Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression.
Yu SX, Du CT, Chen W, Lei QQ, Li N, Qi S, Zhang XJ, Hu GQ, Deng XM, Han WY, Yang YJ
Scientific reports 2015 Dec 11;5:17935
Scientific reports 2015 Dec 11;5:17935
Tissue inhibitor of metalloproteinase-3 knockout mice exhibit enhanced energy expenditure through thermogenesis.
Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H
PloS one 2014;9(4):e94930
PloS one 2014;9(4):e94930
PI3K/Akt/uncoupling protein 2 signaling pathway may be involved in cell senescence and apoptosis induced by angiotensin II in human vascular endothelial cells.
Li P, Guo X, Lei P, Shi S, Luo S, Cheng X
Molecular biology reports 2014 Oct;41(10):6931-7
Molecular biology reports 2014 Oct;41(10):6931-7
Uncoupling protein 2 expression affects androgen synthesis in polycystic ovary syndrome.
Liu Y, Jiang H, Xing FQ, Huang WJ, Mao LH, He LY
Endocrine 2013 Jun;43(3):714-23
Endocrine 2013 Jun;43(3):714-23
Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.
Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Rubin E, Lisanti MP, Sotgia F
Cell cycle (Georgetown, Tex.) 2013 Jan 1;12(1):172-82
Cell cycle (Georgetown, Tex.) 2013 Jan 1;12(1):172-82
Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.
Liu Y, Jiang H, He LY, Huang WJ, He XY, Xing FQ
Reproduction, fertility, and development 2011;23(4):520-6
Reproduction, fertility, and development 2011;23(4):520-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11081-1-AP(UCP2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 11081-1-AP(UCP2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UCP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UCP2. This antibody recognizes human,mouse,rat antigen. The UCP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.