BS9156

antibody from Bioworld Technology, Inc
Targeting: PHF3
Provider product page for BS9156
Western blot
Immunohistochemistry

Antibody data

Product number
BS9156 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PHF3 (D2033) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to the C-terminus of Human PHF3.
Description
PHF3 (PHD finger protein 3) is a 2039 amino acid ubiquitously expressed protein that is phosphorylated upon DNA damage by either ATM or ATR. PHF3 contains a PHD finger motif, a proline-rich region, a TFIIS domain and two bipartite nuclear localization signals. Since these motifs are frequently found in proteins involved in transcription, PHF3 may function as a transcription factor. Expression of PHF3 is significantly reduced in anaplastic astrocytomas, glioblastomas and glioblastoma cell lines, suggesting that PHF3 plays a role as a tumor suppressor. Antibodies against PHF3 are present in some patients afflicted with glioblastoma multiforme and presence of the , correlates to significantly better survival rates. There are two isoforms of PHF3 that are produced as a result of alternative splicing events.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PHF3 protein structure - BS9156 shown in red.