SEMA4G

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Description

Semaphorin 4G

Tissue specificity

Tissue enhanced (intestine, liver)

Subcell location

Vesicles, Lipid droplets

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (100969518 - 100985871)

Ensembl ID

ENSG00000095539  (ver. 103.38)

Orthologs

Mouse Sema4g: ENSMUSG00000025207

UniProt

Q9NTN9

neXtProt

NX_Q9NTN9

Human splice variants
Mouse splice variants

Protein structure