AMM02560G

antibody from Leading Biology

Targeting: CGAS C6orf150, MB21D1

Western blot (Recommended by provider)

Antibody Data

Product number

AMM02560G

Provider

Leading Biology

Product name

MB21D1 Antibody

Antibody type

Monoclonal

Description

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

Reactivity

Human

Host

Mouse

Isotype

IgG

Antibody clone number

1697CT136.65.30

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.