Tissue expression
Cell line expression
Protein structure
MAML2
Mastermind like transcriptional coactivator 2KIAA1819, MAM3
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Top validated antibodies |
|||||
Novus Biologicals | NB100-2127 | 1 references | Polyclonal |
WB
IP
IHC
|
|
LSBio | LS-C680814 | Polyclonal |
WB
EL
IHC
|
||
Biorbyt | orb1460955 | Monoclonal |
WB
ICC
IHC
FC |
||
antibodies-online | ABIN396159 | Monoclonal |
WB
EL
IHC
|
||
NSJ Bioreagents | V3532 | Monoclonal |
WB
ICC
IHC
FC
OA
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider