Tissue expression
Cell line expression
Protein structure
CDK2AP1
Cyclin dependent kinase 2 associated protein 1doc-1, DOC1, DORC1, p12DOC-1, ST19
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Top validated antibodies |
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Proteintech Group | 13060-2-AP | 1 references | Polyclonal |
WB
EL
ICC
|
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LSBio | LS-B9131 | Polyclonal |
WB
EL
IHC
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Invitrogen Antibodies | 13060-2-AP | Polyclonal |
WB
ICC
IHC
|
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OriGene | TA590189 | Polyclonal |
WB
EL
IHC
|
||
Affinity Biosciences | AF0309 | Polyclonal |
WB
EL
ICC
|
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