CCR10

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]). [supplied by OMIM, Mar 2008]

Description

C-C motif chemokine receptor 10

Tissue specificity

Tissue enhanced (pituitary gland)

Subcell location

Endoplasmic reticulum

Predicted location

Membrane

Protein family

Cancer-related genes
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins

Chromosome

17 (42678889 - 42683917)

Ensembl ID

ENSG00000184451  (ver. 103.38)

Orthologs

Mouse Ccr10: ENSMUSG00000044052

UniProt

P46092

neXtProt

NX_P46092

Human splice variants
Mouse splice variants

Protein structure