CDC42EP4

The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]

Description

CDC42 effector protein 4

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Actin filaments, Microtubules

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (73283624 - 73312005)

Ensembl ID

ENSG00000179604  (ver. 103.38)

Orthologs

Mouse Cdc42ep4: ENSMUSG00000041598

UniProt

Q9H3Q1

neXtProt

NX_Q9H3Q1

Human splice variants
Mouse splice variants

Protein structure