H00064446-M01

antibody from Abnova Corporation

Targeting: DNAI2 CILD9, DIC2

Provider product page for H00064446-M01

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [6]
Comments [0]
Validations
Western blot [2]
ELISA [1]
Immunocytochemistry [1]

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Product number: H00064446-M01 - Provider product page
Provider: Abnova Corporation
Proper citation: Abnova Corporation Cat#H00064446-M01, RRID:AB_426059
Product name: DNAI2 monoclonal antibody (M01), clone 1C8
Antibody type: Monoclonal
Description: Mouse monoclonal antibody raised against a full length recombinant DNAI2.
Antigen sequence: MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIMPNP ELAEQFVERNPVDTGIQCSISMSEHEANSERFEME TRGVNHVEGGWPKDVNPLELEQTIRFRKKVEKDEN YVNAIMQLGSIMEHCIKQNNAIDIYEEYFNDEEAM EVMEEDPSAKTINVFRDPQEIKRAATHLSWHPDGN RKLAVAYSCLDFQRAPVGMSSDSYIWDLENPNKPE LALKPSSPLVTLEFNPKDSHVLLGGCYNGQIACWD TRKGSLVAELSTIESSHRDPVYGTIWLQSKTGTEC FSASTDGQVMWWDIRKMSEPTEVVILDITKKEQLE NALGAISLEFESTLPTKFMVGTEQGIVISCNRKAK TSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGD WTARIWSEDSRESSIMWTKYHMAYLTDAAWSPVRP TVFFTTRMDGTLDIWDFMFEQCDPTLSLKDNGCLI ACGSQLGTTTLLEVSPGLSTLQRNEKNVASSMFER ETRREKILEARHREMRLKEKGKAEGRDEEQTDEEL AVDLEALVSKAEEEFFDIIFTELKKKEADAIKLTP VPQQPSPEEDQVVEEGEEAAGEEGDEEVEEDLA
Isotype: IgG
Antibody clone number: 1C8
Storage: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

DNAI2 protein structure - H00064446-M01 shown in red.

Submitted references HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.

Diggle CP, Moore DJ, Mali G, zur Lage P, Ait-Lounis A, Schmidts M, Shoemark A, Garcia Munoz A, Halachev MR, Gautier P, Yeyati PL, Bonthron DT, Carr IM, Hayward B, Markham AF, Hope JE, von Kriegsheim A, Mitchison HM, Jackson IJ, Durand B, Reith W, Sheridan E, Jarman AP, Mill P
PLoS genetics 2014 Sep;10(9):e1004577

Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.

Dong F, Shinohara K, Botilde Y, Nabeshima R, Asai Y, Fukumoto A, Hasegawa T, Matsuo M, Takeda H, Shiratori H, Nakamura T, Hamada H
The Journal of cell biology 2014 Jan 20;204(2):203-13

Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.

Ben Khelifa M, Coutton C, Zouari R, Karaouzène T, Rendu J, Bidart M, Yassine S, Pierre V, Delaroche J, Hennebicq S, Grunwald D, Escalier D, Pernet-Gallay K, Jouk PS, Thierry-Mieg N, Touré A, Arnoult C, Ray PF
American journal of human genetics 2014 Jan 2;94(1):95-104

DYX1C1 is required for axonemal dynein assembly and ciliary motility.

Tarkar A, Loges NT, Slagle CE, Francis R, Dougherty GW, Tamayo JV, Shook B, Cantino M, Schwartz D, Jahnke C, Olbrich H, Werner C, Raidt J, Pennekamp P, Abouhamed M, Hjeij R, Köhler G, Griese M, Li Y, Lemke K, Klena N, Liu X, Gabriel G, Tobita K, Jaspers M, Morgan LC, Shapiro AJ, Letteboer SJ, Mans DA, Carson JL, Leigh MW, Wolf WE, Chen S, Lucas JS, Onoufriadis A, Plagnol V, Schmidts M, Boldt K, UK10K, Roepman R, Zariwala MA, Lo CW, Mitchison HM, Knowles MR, Burdine RD, Loturco JJ, Omran H
Nature genetics 2013 Sep;45(9):995-1003

DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.

Loges NT, Olbrich H, Fenske L, Mussaffi H, Horvath J, Fliegauf M, Kuhl H, Baktai G, Peterffy E, Chodhari R, Chung EM, Rutman A, O'Callaghan C, Blau H, Tiszlavicz L, Voelkel K, Witt M, Zietkiewicz E, Neesen J, Reinhardt R, Mitchison HM, Omran H
American journal of human genetics 2008 Nov;83(5):547-58

Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins.

Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges NT, Hagiwara H, Zhang Q, Leblond G, O'Toole E, Hara C, Mizuno H, Kawano H, Fliegauf M, Yagi T, Koshida S, Miyawaki A, Zentgraf H, Seithe H, Reinhardt R, Watanabe Y, Kamiya R, Mitchell DR, Takeda H
Nature 2008 Dec 4;456(7222):611-6