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Protein structure
BMP8B
Bone morphogenetic protein 8bBMP8, OP-2
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]
Top validated antibodies |
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| Biorbyt |  orb4697 |
Polyclonal |
WB
EL
ICC
IHC
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| LSBio | LS-B11364 |
Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NBP2-42693 |
Monoclonal |
WB
EL
ICC
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| Antibodies.com | A55116 |
Polyclonal |
WB
EL
IP
|
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| Affinity Biosciences | DF3850 |
Polyclonal |
WB
EL
ICC
|
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