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LearnNB110-53818
antibody from Novus Biologicals
Targeting: ATG5
APG5, APG5L, ASP, hAPG5
Western blot
ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Immunoelectron microscopy Radioimmunoassay Proximity ligation assayAntibody data
- Antibody Data
- Antigen structure
- References [187]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [3]
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- Product number
- NB110-53818 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB110-53818, RRID:AB_828587
- Product name
- Rabbit Polyclonal ATG5 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. This is selective for the full-length and calpain cleaved isoform proteins. The short isoform is missing amino acids 1-79. The calpain cleaved form of ATG5 is missing amino acids 195-275.
- Reactivity
- Human, Mouse, Rat, Bovine, Guinea Pig, Porcine, Simian, Xenopus, Zebrafish
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis.
Detection and analysis of autophagy in the American alligator (Alligator mississippiensis).
CCN1 triggers adaptive autophagy in cardiomyocytes to curb its apoptotic activities.
Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression.
Mitigation of ALS Pathology by Neuron-Specific Inhibition of Nuclear Factor Kappa B Signaling.
Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish.
RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations.
Short communication: Enhanced autophagy activity in liver tissue of dairy cows with mild fatty liver.
HIV Tat-mediated induction of autophagy regulates the disruption of ZO-1 in brain endothelial cells.
ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy.
Lead Induced Ototoxicity and Neurotoxicity in Adult Guinea Pig.
Classical Swine Fever Virus Infection Induces Endoplasmic Reticulum Stress-Mediated Autophagy to Sustain Viral Replication in vivo and in vitro.
Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation.
Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats.
The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage.
Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes.
ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling.
Isarubrolones Containing a Pyridooxazinium Unit from Streptomyces as Autophagy Activators.
LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease.
Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy.
TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.
Atg5 Supports Rickettsia australis Infection in Macrophages In Vitro and In Vivo.
Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.
ATG5 is required for B cell polarization and presentation of particulate antigens.
Dehydrocostus lactone suppresses osteoclast differentiation by regulating NFATc1 and inhibits osteoclast activation through modulating migration and lysosome function.
TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction.
Compressive stress-induced autophagy promotes invasion of HeLa cells by facilitating protein turnover in vitro.
RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways.
Oncolytic Newcastle disease virus induces autophagy-dependent immunogenic cell death in lung cancer cells.
Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis.
Inhibiting autophagy reduces retinal degeneration caused by protein misfolding.
Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1.
mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.
Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis.
Halofuginone-induced autophagy suppresses the migration and invasion of MCF-7 cells via regulation of STMN1 and p53.
Role of Fibroblast Growth Factor Receptor 2b in the Cross Talk between Autophagy and Differentiation: Involvement of Jun N-Terminal Protein Kinase Signaling.
Inflachromene inhibits autophagy through modulation of Beclin 1 activity.
Nano-sized Al2O3 particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts.
microRNA-199a/b-5p enhance imatinib efficacy via repressing WNT2 signaling-mediated protective autophagy in imatinib-resistant chronic myeloid leukemia cells.
CD4 T cell autophagy is integral to memory maintenance.
The Autophagy Level Is Increased in the Synovial Tissues of Patients with Active Rheumatoid Arthritis and Is Correlated with Disease Severity.
Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.
Genetic polymorphisms of ATG5 predict survival and recurrence in patients with early-stage esophageal squamous cell carcinoma.
MG-132 reduces virus release in Bovine herpesvirus-1 infection.
Compromised autophagy precedes meniscus degeneration and cartilage damage in mice.
Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism.
Mir-30d suppresses cell proliferation of colon cancer cells by inhibiting cell autophagy and promoting cell apoptosis.
Osmotic Stress-Induced Defective Glial Proteostasis Contributes to Brain Demyelination after Hyponatremia Treatment.
Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.
Mechanisms of autophagy induction by sex steroids in bovine mammary epithelial cells.
Bassoon Controls Presynaptic Autophagy through Atg5.
Elevation of autophagy markers in Sjögren syndrome dry eye.
System-wide Benefits of Intermeal Fasting by Autophagy.
Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration.
The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress.
Autophagy upregulation ameliorates cell injury in Sequestosome 1 knockout podocytes in vitro.
Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells.
Human Rad23A plays a regulatory role in autophagy.
Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy.
Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis.
Arginine Supplementation Recovered the IFN-γ-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2α Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells.
Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3.
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments.
Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow.
Chaperone-like protein HYPK and its interacting partners augment autophagy.
Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes.
Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes.
TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction.
Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver.
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure.
MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-2.
Measuring autophagy in stressed cells.
Evolutionary trends and functional anatomy of the human expanded autophagy network.
The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells.
Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.
Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency.
Identification of secreted proteins that reflect autophagy dynamics within tumor cells.
Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity.
Trehalose-mediated autophagy impairs the anti-viral function of human primary airway epithelial cells.
Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1.
Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion.
Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria.
Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells.
Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma.
Xylitol induces cell death in lung cancer A549 cells by autophagy.
NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice.
A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in macrophages and zebrafish.
Autophagy in zebrafish.
The generation of neutrophils in the bone marrow is controlled by autophagy.
Centrin2 regulates CP110 removal in primary cilium formation.
The relationship of autophagy defects to cartilage damage during joint aging in a mouse model.
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.
PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.
Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy.
HIV-1 and morphine regulation of autophagy in microglia: limited interactions in the context of HIV-1 infection and opioid abuse.
The GTPase Rab26 links synaptic vesicles to the autophagy pathway.
In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy.
β-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy.
Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.
MicroRNA-20a regulates autophagy related protein-ATG16L1 in hypoxia-induced osteoclast differentiation.
The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.
Growth factor receptor-bound protein 2 promotes autophagic removal of amyloid-β protein precursor intracellular domain overload in neuronal cells.
Functional interactions between 17 β -estradiol and progesterone regulate autophagy during acini formation by bovine mammary epithelial cells in 3D cultures.
Distinct lysosome phenotypes influence inflammatory function in peritoneal and bone marrow-derived macrophages.
Role of VAMP3 and VAMP7 in the commitment of Yersinia pseudotuberculosis to LC3-associated pathways involving single- or double-membrane vacuoles.
Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression.
Dynamic involvement of ATG5 in cellular stress responses.
Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication.
Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.
Autophagy induced by tumor necrosis factor α mediates intrinsic apoptosis in trophoblastic cells.
Connexins modulate autophagosome biogenesis.
FGF7/KGF regulates autophagy in keratinocytes: A novel dual role in the induction of both assembly and turnover of autophagosomes.
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.
Autophagy enhances the replication of classical swine fever virus in vitro.
Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection.
Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation.
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Suppression of autophagic activation in the mouse uterus by estrogen and progesterone.
Autophagy is required for zebrafish caudal fin regeneration.
Dissection of autophagy in human platelets.
Autophagy is essential for cardiac morphogenesis during vertebrate development.
DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV.
JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.
Adiponectin modulates oxidative stress-induced autophagy in cardiomyocytes.
Peroxisome proliferator-activated receptor δ agonist, HPP593, prevents renal necrosis under chronic ischemia.
Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma.
Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.
Autophagy proteins regulate ERK phosphorylation.
The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer.
Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development.
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.
Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory syncytial virus infection.
Deletion of ATG5 shows a role of autophagy in salivary homeostatic control.
Epigenetic regulation of autophagy by the methyltransferase G9a.
Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells.
Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury.
Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation.
Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells.
Identification of autophagic vacuoles and regulators of autophagy in villous trophoblast from normal term pregnancies and in fetal growth restriction.
Autophagy protects the retina from light-induced degeneration.
Intestinal epithelial autophagy is essential for host defense against invasive bacteria.
Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation.
Autophagy is required for IL-2-mediated fibroblast growth.
Identification of a candidate therapeutic autophagy-inducing peptide.
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.
Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation.
Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.
Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress.
Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure.
RNase L triggers autophagy in response to viral infections.
Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy.
The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.
Induction of autophagy is essential for monocyte-macrophage differentiation.
Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice.
Age-related oxidative stress compromises endosomal proteostasis.
β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells.
IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.
Autophagy is involved in the early step of Japanese encephalitis virus infection.
Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells.
Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells.
Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease.
Autophagy links inflammasomes to atherosclerotic progression.
Autophagy positively regulates the CD44(+) CD24(-/low) breast cancer stem-like phenotype.
Autophagy regulates embryonic survival during delayed implantation.
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.
Silica nanoconstruct cellular toleration threshold in vitro.
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.
PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase.
Calcipotriol induces autophagy in HeLa cells and keratinocytes.
Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival.
Rosetta FlexPepDock ab-initio: simultaneous folding, docking and refinement of peptides onto their receptors.
Entrapment of intracytosolic bacteria by septin cage-like structures.
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection.
Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia.
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus.
Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death.
Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death.
An HK, Chung KM, Park H, Hong J, Gim JE, Choi H, Lee YW, Choi J, Mun JY, Yu SW
Autophagy 2020 Sep;16(9):1598-1617
Autophagy 2020 Sep;16(9):1598-1617
Detection and analysis of autophagy in the American alligator (Alligator mississippiensis).
Hale A, Merchant M, White M
Journal of experimental zoology. Part B, Molecular and developmental evolution 2020 May;334(3):192-207
Journal of experimental zoology. Part B, Molecular and developmental evolution 2020 May;334(3):192-207
CCN1 triggers adaptive autophagy in cardiomyocytes to curb its apoptotic activities.
Su BC, Hsu PL, Mo FE
Journal of cell communication and signaling 2020 Mar;14(1):93-100
Journal of cell communication and signaling 2020 Mar;14(1):93-100
Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression.
Marsh T, Kenific CM, Suresh D, Gonzalez H, Shamir ER, Mei W, Tankka A, Leidal AM, Kalavacherla S, Woo K, Werb Z, Debnath J
Developmental cell 2020 Mar 9;52(5):591-604.e6
Developmental cell 2020 Mar 9;52(5):591-604.e6
Mitigation of ALS Pathology by Neuron-Specific Inhibition of Nuclear Factor Kappa B Signaling.
Dutta K, Thammisetty SS, Boutej H, Bareil C, Julien JP
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Jun 24;40(26):5137-5154
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Jun 24;40(26):5137-5154
Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish.
Mawed SA, He Y, Zhang J, Mei J
International journal of molecular sciences 2020 Feb 24;21(4)
International journal of molecular sciences 2020 Feb 24;21(4)
RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations.
Bekbulat F, Schmitt D, Feldmann A, Huesmann H, Eimer S, Juretschke T, Beli P, Behl C, Kern A
Journal of molecular biology 2020 Feb 14;432(4):1216-1234
Journal of molecular biology 2020 Feb 14;432(4):1216-1234
Short communication: Enhanced autophagy activity in liver tissue of dairy cows with mild fatty liver.
Chen M, Loor JJ, Zhai Q, Liang Y, Yu H, Du X, Shen T, Fang Z, Shi Z, Wang X, Zhu Y, Song Y, Liu G, Li X, Wang Z, Li X
Journal of dairy science 2020 Apr;103(4):3628-3635
Journal of dairy science 2020 Apr;103(4):3628-3635
HIV Tat-mediated induction of autophagy regulates the disruption of ZO-1 in brain endothelial cells.
Liao K, Niu F, Hu G, Guo ML, Sil S, Buch S
Tissue barriers 2020 Apr 2;8(2):1748983
Tissue barriers 2020 Apr 2;8(2):1748983
ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy.
Wible DJ, Chao HP, Tang DG, Bratton SB
Cell discovery 2019;5:42
Cell discovery 2019;5:42
Lead Induced Ototoxicity and Neurotoxicity in Adult Guinea Pig.
Zhang Y, Jiang Q, Xie S, Wu X, Zhou J, Sun H
BioMed research international 2019;2019:3626032
BioMed research international 2019;2019:3626032
Classical Swine Fever Virus Infection Induces Endoplasmic Reticulum Stress-Mediated Autophagy to Sustain Viral Replication in vivo and in vitro.
Zhu E, Chen W, Qin Y, Ma S, Fan S, Wu K, Li W, Fan J, Yi L, Ding H, Chen J, Zhao M
Frontiers in microbiology 2019;10:2545
Frontiers in microbiology 2019;10:2545
Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation.
Shin JH, Park SJ, Jo DS, Park NY, Kim JB, Bae JE, Jo YK, Hwang JJ, Lee JA, Jo DG, Kim JC, Jung YK, Koh JY, Cho DH
Autophagy 2019 Sep;15(9):1495-1505
Autophagy 2019 Sep;15(9):1495-1505
Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats.
Sun CM, Enkhjargal B, Reis C, Zhou KR, Xie ZY, Wu LY, Zhang TY, Zhu QQ, Tang JP, Jiang XD, Zhang JH
CNS neuroscience & therapeutics 2019 Oct;25(10):1162-1172
CNS neuroscience & therapeutics 2019 Oct;25(10):1162-1172
The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage.
Koerver L, Papadopoulos C, Liu B, Kravic B, Rota G, Brecht L, Veenendaal T, Polajnar M, Bluemke A, Ehrmann M, Klumperman J, Jäättelä M, Behrends C, Meyer H
EMBO reports 2019 Oct 4;20(10):e48014
EMBO reports 2019 Oct 4;20(10):e48014
Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes.
Liu YT, Lai YH, Lin HH, Chen JH
Nutrients 2019 Nov 28;11(12)
Nutrients 2019 Nov 28;11(12)
ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling.
Zheng W, Xie W, Yin D, Luo R, Liu M, Guo F
Cell communication and signaling : CCS 2019 May 6;17(1):42
Cell communication and signaling : CCS 2019 May 6;17(1):42
Isarubrolones Containing a Pyridooxazinium Unit from Streptomyces as Autophagy Activators.
Li L, Li S, Jiang B, Zhang M, Zhang J, Yang B, Li L, Yu L, Liu H, You X, Hu X, Wang Z, Li Y, Wu L
Journal of natural products 2019 May 24;82(5):1149-1154
Journal of natural products 2019 May 24;82(5):1149-1154
LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease.
Bonello F, Hassoun SM, Mouton-Liger F, Shin YS, Muscat A, Tesson C, Lesage S, Beart PM, Brice A, Krupp J, Corvol JC, Corti O
Human molecular genetics 2019 May 15;28(10):1645-1660
Human molecular genetics 2019 May 15;28(10):1645-1660
Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy.
Hu Z, Chen B, Zhao Q
Biology open 2019 May 1;8(5)
Biology open 2019 May 1;8(5)
TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.
Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, Méndez-Solís O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, Youseff BH, Ireland RM, Bosio CM, Kim K, Luban J, Hirsch VM, Taylor RT, Bouamr F, Sawyer SL, Best SM
Cell reports 2019 Jun 11;27(11):3269-3283.e6
Cell reports 2019 Jun 11;27(11):3269-3283.e6
Atg5 Supports Rickettsia australis Infection in Macrophages In Vitro and In Vivo.
Bechelli J, Vergara L, Smalley C, Buzhdygan TP, Bender S, Zhang W, Liu Y, Popov VL, Wang J, Garg N, Hwang S, Walker DH, Fang R
Infection and immunity 2019 Jan;87(1)
Infection and immunity 2019 Jan;87(1)
Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.
Görgülü K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, Ciecielski KJ, Kaya-Aksoy E, Ruess DA, Berninger A, Kowalska M, Stevanovic M, Wörmann SM, Wartmann T, Zhao Y, Halangk W, Voronina S, Tepikin A, Schlitter AM, Steiger K, Artati A, Adamski J, Aichler M, Walch A, Jastroch M, Hartleben G, Mantzoros CS, Weichert W, Schmid RM, Herzig S, Krüger A, Sainz B Jr, Lesina M, Algül H
Gastroenterology 2019 Jan;156(1):203-217.e20
Gastroenterology 2019 Jan;156(1):203-217.e20
ATG5 is required for B cell polarization and presentation of particulate antigens.
Arbogast F, Arnold J, Hammann P, Kuhn L, Chicher J, Murera D, Weishaar J, Muller S, Fauny JD, Gros F
Autophagy 2019 Feb;15(2):280-294
Autophagy 2019 Feb;15(2):280-294
Dehydrocostus lactone suppresses osteoclast differentiation by regulating NFATc1 and inhibits osteoclast activation through modulating migration and lysosome function.
Lee HI, Lee J, Hwang D, Lee GR, Kim N, Kwon M, Lee H, Piao D, Kim HJ, Kim NY, Kim HS, Seo EK, Kang D, Jeong W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9685-9694
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Aug;33(8):9685-9694
TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction.
You Z, Xu Y, Wan W, Zhou L, Li J, Zhou T, Shi Y, Liu W
Autophagy 2019 Aug;15(8):1309-1321
Autophagy 2019 Aug;15(8):1309-1321
Compressive stress-induced autophagy promotes invasion of HeLa cells by facilitating protein turnover in vitro.
Das J, Agarwal T, Chakraborty S, Maiti TK
Experimental cell research 2019 Aug 15;381(2):201-207
Experimental cell research 2019 Aug 15;381(2):201-207
RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways.
Wu XM, Chen WQ, Hu YW, Cao L, Nie P, Chang MX
Frontiers in immunology 2018;9:726
Frontiers in immunology 2018;9:726
Oncolytic Newcastle disease virus induces autophagy-dependent immunogenic cell death in lung cancer cells.
Ye T, Jiang K, Wei L, Barr MP, Xu Q, Zhang G, Ding C, Meng S, Piao H
American journal of cancer research 2018;8(8):1514-1527
American journal of cancer research 2018;8(8):1514-1527
Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis.
Lin HH, Chung Y, Cheng CT, Ouyang C, Fu Y, Kuo CY, Chi KK, Sadeghi M, Chu P, Kung HJ, Li CF, Limesand KH, Ann DK
Autophagy 2018;14(9):1481-1498
Autophagy 2018;14(9):1481-1498
Inhibiting autophagy reduces retinal degeneration caused by protein misfolding.
Yao J, Qiu Y, Frontera E, Jia L, Khan NW, Klionsky DJ, Ferguson TA, Thompson DA, Zacks DN
Autophagy 2018;14(7):1226-1238
Autophagy 2018;14(7):1226-1238
Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1.
Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, Zhang S, Gao H, Wang P, Zhang Z, Luo J, Li Z
Autophagy 2018;14(2):336-346
Autophagy 2018;14(2):336-346
mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.
Wan W, You Z, Zhou L, Xu Y, Peng C, Zhou T, Yi C, Shi Y, Liu W
Molecular cell 2018 Oct 18;72(2):303-315.e6
Molecular cell 2018 Oct 18;72(2):303-315.e6
Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis.
Dutta K, Patel P, Julien JP
Experimental neurology 2018 Nov;309:193-204
Experimental neurology 2018 Nov;309:193-204
Halofuginone-induced autophagy suppresses the migration and invasion of MCF-7 cells via regulation of STMN1 and p53.
Xia X, Wang L, Zhang X, Wang S, Lei L, Cheng L, Xu Y, Sun Y, Hang B, Zhang G, Bai Y, Hu J
Journal of cellular biochemistry 2018 May;119(5):4009-4020
Journal of cellular biochemistry 2018 May;119(5):4009-4020
Role of Fibroblast Growth Factor Receptor 2b in the Cross Talk between Autophagy and Differentiation: Involvement of Jun N-Terminal Protein Kinase Signaling.
Nanni M, Ranieri D, Rosato B, Torrisi MR, Belleudi F
Molecular and cellular biology 2018 Jul 1;38(13)
Molecular and cellular biology 2018 Jul 1;38(13)
Inflachromene inhibits autophagy through modulation of Beclin 1 activity.
Kim YH, Kwak MS, Shin JM, Hayuningtyas RA, Choi JE, Shin JS
Journal of cell science 2018 Feb 20;131(4)
Journal of cell science 2018 Feb 20;131(4)
Nano-sized Al2O3 particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts.
Li, Wang C, Li Z, Wang H, He J, Zhu J, Zhang Y, Shen C, Xiao F, Gao Y, Zhang X, Li Y, Wang P, Peng J, Cai G, Zuo B, Yang Y, Shen Y, Song W, Zhang X, Shen L, Chen X
Cell death & disease 2018 Aug 6;9(8):840
Cell death & disease 2018 Aug 6;9(8):840
microRNA-199a/b-5p enhance imatinib efficacy via repressing WNT2 signaling-mediated protective autophagy in imatinib-resistant chronic myeloid leukemia cells.
Chen PH, Liu AJ, Ho KH, Chiu YT, Anne Lin ZH, Lee YT, Shih CM, Chen KC
Chemico-biological interactions 2018 Aug 1;291:144-151
Chemico-biological interactions 2018 Aug 1;291:144-151
CD4 T cell autophagy is integral to memory maintenance.
Murera D, Arbogast F, Arnold J, Bouis D, Muller S, Gros F
Scientific reports 2018 Apr 13;8(1):5951
Scientific reports 2018 Apr 13;8(1):5951
The Autophagy Level Is Increased in the Synovial Tissues of Patients with Active Rheumatoid Arthritis and Is Correlated with Disease Severity.
Zhu L, Wang H, Wu Y, He Z, Qin Y, Shen Q
Mediators of inflammation 2017;2017:7623145
Mediators of inflammation 2017;2017:7623145
Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.
Kuss-Duerkop SK, Wang J, Mena I, White K, Metreveli G, Sakthivel R, Mata MA, Muñoz-Moreno R, Chen X, Krammer F, Diamond MS, Chen ZJ, García-Sastre A, Fontoura BMA
PLoS pathogens 2017 Sep;13(9):e1006635
PLoS pathogens 2017 Sep;13(9):e1006635
Genetic polymorphisms of ATG5 predict survival and recurrence in patients with early-stage esophageal squamous cell carcinoma.
Yang PW, Hsieh MS, Chang YH, Huang PM, Lee JM
Oncotarget 2017 Oct 31;8(53):91494-91504
Oncotarget 2017 Oct 31;8(53):91494-91504
MG-132 reduces virus release in Bovine herpesvirus-1 infection.
Fiorito F, Iovane V, Cantiello A, Marullo A, De Martino L, Iovane G
Scientific reports 2017 Oct 17;7(1):13306
Scientific reports 2017 Oct 17;7(1):13306
Compromised autophagy precedes meniscus degeneration and cartilage damage in mice.
Meckes JK, Caramés B, Olmer M, Kiosses WB, Grogan SP, Lotz MK, D'Lima DD
Osteoarthritis and cartilage 2017 Nov;25(11):1880-1889
Osteoarthritis and cartilage 2017 Nov;25(11):1880-1889
Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism.
Maus M, Cuk M, Patel B, Lian J, Ouimet M, Kaufmann U, Yang J, Horvath R, Hornig-Do HT, Chrzanowska-Lightowlers ZM, Moore KJ, Cuervo AM, Feske S
Cell metabolism 2017 Mar 7;25(3):698-712
Cell metabolism 2017 Mar 7;25(3):698-712
Mir-30d suppresses cell proliferation of colon cancer cells by inhibiting cell autophagy and promoting cell apoptosis.
Zhang R, Xu J, Zhao J, Bai J
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jun;39(6):1010428317703984
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jun;39(6):1010428317703984
Osmotic Stress-Induced Defective Glial Proteostasis Contributes to Brain Demyelination after Hyponatremia Treatment.
Gankam-Kengne F, Couturier BS, Soupart A, Brion JP, Decaux G
Journal of the American Society of Nephrology : JASN 2017 Jun;28(6):1802-1813
Journal of the American Society of Nephrology : JASN 2017 Jun;28(6):1802-1813
Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.
Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR
Cell metabolism 2017 Jun 6;25(6):1320-1333.e5
Cell metabolism 2017 Jun 6;25(6):1320-1333.e5
Mechanisms of autophagy induction by sex steroids in bovine mammary epithelial cells.
Zielniok K, Sobolewska A, Gajewska M
Journal of molecular endocrinology 2017 Jul;59(1):29-48
Journal of molecular endocrinology 2017 Jul;59(1):29-48
Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron 2017 Feb 22;93(4):897-913.e7
Neuron 2017 Feb 22;93(4):897-913.e7
Elevation of autophagy markers in Sjögren syndrome dry eye.
Byun YS, Lee HJ, Shin S, Chung SH
Scientific reports 2017 Dec 8;7(1):17280
Scientific reports 2017 Dec 8;7(1):17280
System-wide Benefits of Intermeal Fasting by Autophagy.
Martinez-Lopez N, Tarabra E, Toledo M, Garcia-Macia M, Sahu S, Coletto L, Batista-Gonzalez A, Barzilai N, Pessin JE, Schwartz GJ, Kersten S, Singh R
Cell metabolism 2017 Dec 5;26(6):856-871.e5
Cell metabolism 2017 Dec 5;26(6):856-871.e5
Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration.
Baron O, Boudi A, Dias C, Schilling M, Nölle A, Vizcay-Barrena G, Rattray I, Jungbluth H, Scheper W, Fleck RA, Bates GP, Fanto M
Current biology : CB 2017 Dec 4;27(23):3626-3642.e6
Current biology : CB 2017 Dec 4;27(23):3626-3642.e6
The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress.
Mans LA, Querol Cano L, van Pelt J, Giardoglou P, Keune WJ, Haramis AG
Scientific reports 2017 Aug 4;7(1):7327
Scientific reports 2017 Aug 4;7(1):7327
Autophagy upregulation ameliorates cell injury in Sequestosome 1 knockout podocytes in vitro.
Li Z, Yuan Y, Meng Y, Rong Y, Bai H, Chen L
Biochemical and biophysical research communications 2017 Aug 19;490(2):98-103
Biochemical and biophysical research communications 2017 Aug 19;490(2):98-103
Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells.
Xia XJ, Gao YY, Zhang J, Wang L, Zhao S, Che YY, Ao CJ, Yang HJ, Wang JQ, Lei LC
Cell death discovery 2016;2:15065
Cell death discovery 2016;2:15065
Human Rad23A plays a regulatory role in autophagy.
Tan X, Wang HC, Liang RY, Chuang SM
Biochemical and biophysical research communications 2016 Sep 30;478(4):1772-9
Biochemical and biophysical research communications 2016 Sep 30;478(4):1772-9
Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy.
Cai Y, Yang L, Hu G, Chen X, Niu F, Yuan L, Liu H, Xiong H, Arikkath J, Buch S
The Journal of cell biology 2016 Oct 24;215(2):245-258
The Journal of cell biology 2016 Oct 24;215(2):245-258
Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis.
Lee E, Wei Y, Zou Z, Tucker K, Rakheja D, Levine B, Amatruda JF
Oncotarget 2016 Oct 18;7(42):67919-67933
Oncotarget 2016 Oct 18;7(42):67919-67933
Arginine Supplementation Recovered the IFN-γ-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2α Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells.
Xia X, Che Y, Gao Y, Zhao S, Ao C, Yang H, Liu J, Liu G, Han W, Wang Y, Lei L
Molecules and cells 2016 May 31;39(5):410-7
Molecules and cells 2016 May 31;39(5):410-7
Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3.
Sharifi MN, Mowers EE, Drake LE, Collier C, Chen H, Zamora M, Mui S, Macleod KF
Cell reports 2016 May 24;15(8):1660-72
Cell reports 2016 May 24;15(8):1660-72
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
Developmental cell 2016 May 23;37(4):337-349
Developmental cell 2016 May 23;37(4):337-349
Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments.
Baisantry A, Bhayana S, Rong S, Ermeling E, Wrede C, Hegermann J, Pennekamp P, Sörensen-Zender I, Haller H, Melk A, Schmitt R
Journal of the American Society of Nephrology : JASN 2016 Jun;27(6):1609-16
Journal of the American Society of Nephrology : JASN 2016 Jun;27(6):1609-16
Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow.
Orhon I, Dupont N, Zaidan M, Boitez V, Burtin M, Schmitt A, Capiod T, Viau A, Beau I, Kuehn EW, Friedlander G, Terzi F, Codogno P
Nature cell biology 2016 Jun;18(6):657-67
Nature cell biology 2016 Jun;18(6):657-67
Chaperone-like protein HYPK and its interacting partners augment autophagy.
Choudhury KR, Bucha S, Baksi S, Mukhopadhyay D, Bhattacharyya NP
European journal of cell biology 2016 Jun-Jul;95(6-7):182-94
European journal of cell biology 2016 Jun-Jul;95(6-7):182-94
Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes.
Choi MS, Kim HJ, Ham M, Choi DH, Lee TR, Shin DW
Scientific reports 2016 Jun 27;6:28476
Scientific reports 2016 Jun 27;6:28476
Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes.
Yun WJ, Kim EY, Park JE, Jo SY, Bang SH, Chang EJ, Chang SE
Scientific reports 2016 Jan 27;6:19914
Scientific reports 2016 Jan 27;6:19914
TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction.
Imam S, Talley S, Nelson RS, Dharan A, O'Connor C, Hope TJ, Campbell EM
Journal of virology 2016 Jan 13;90(7):3400-10
Journal of virology 2016 Jan 13;90(7):3400-10
Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver.
Martinez-Lopez N, Garcia-Macia M, Sahu S, Athonvarangkul D, Liebling E, Merlo P, Cecconi F, Schwartz GJ, Singh R
Cell metabolism 2016 Jan 12;23(1):113-27
Cell metabolism 2016 Jan 12;23(1):113-27
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, Rostker F, Krummel M, Debnath J
The Journal of clinical investigation 2016 Dec 1;126(12):4417-4429
The Journal of clinical investigation 2016 Dec 1;126(12):4417-4429
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC
Nature 2016 Aug 25;536(7617):479-83
Nature 2016 Aug 25;536(7617):479-83
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.
Song JX, Sun YR, Peluso I, Zeng Y, Yu X, Lu JH, Xu Z, Wang MZ, Liu LF, Huang YY, Chen LL, Durairajan SS, Zhang HJ, Zhou B, Zhang HQ, Lu A, Ballabio A, Medina DL, Guo Z, Li M
Autophagy 2016 Aug 2;12(8):1372-89
Autophagy 2016 Aug 2;12(8):1372-89
Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure.
Dever SM, Rodriguez M, Lapierre J, Costin BN, El-Hage N
Frontiers in microbiology 2015;6:653
Frontiers in microbiology 2015;6:653
MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-2.
Zhang F, Wang J, Chu J, Yang C, Xiao H, Zhao C, Sun Z, Gao X, Chen G, Han Z, Zou W, Liu T
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;37(4):1442-53
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;37(4):1442-53
Measuring autophagy in stressed cells.
Sharifi MN, Mowers EE, Drake LE, Macleod KF
Methods in molecular biology (Clifton, N.J.) 2015;1292:129-50
Methods in molecular biology (Clifton, N.J.) 2015;1292:129-50
Evolutionary trends and functional anatomy of the human expanded autophagy network.
Till A, Saito R, Merkurjev D, Liu JJ, Syed GH, Kolnik M, Siddiqui A, Glas M, Scheffler B, Ideker T, Subramani S
Autophagy 2015;11(9):1652-67
Autophagy 2015;11(9):1652-67
The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells.
Johansson I, Monsen VT, Pettersen K, Mildenberger J, Misund K, Kaarniranta K, Schønberg S, Bjørkøy G
Autophagy 2015;11(9):1636-51
Autophagy 2015;11(9):1636-51
Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.
Yao J, Jia L, Khan N, Lin C, Mitter SK, Boulton ME, Dunaief JL, Klionsky DJ, Guan JL, Thompson DA, Zacks DN
Autophagy 2015;11(6):939-53
Autophagy 2015;11(6):939-53
Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency.
Kim Y, Kang YS, Lee NY, Kim KY, Hwang YJ, Kim HW, Rhyu IJ, Her S, Jung MK, Kim S, Lee CJ, Ko S, Kowall NW, Lee SB, Lee J, Ryu H
Autophagy 2015;11(5):796-811
Autophagy 2015;11(5):796-811
Identification of secreted proteins that reflect autophagy dynamics within tumor cells.
Kraya AA, Piao S, Xu X, Zhang G, Herlyn M, Gimotty P, Levine B, Amaravadi RK, Speicher DW
Autophagy 2015;11(1):60-74
Autophagy 2015;11(1):60-74
Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity.
Malhotra R, Warne JP, Salas E, Xu AW, Debnath J
Autophagy 2015;11(1):145-54
Autophagy 2015;11(1):145-54
Trehalose-mediated autophagy impairs the anti-viral function of human primary airway epithelial cells.
Wu Q, Jiang D, Huang C, van Dyk LF, Li L, Chu HW
PloS one 2015;10(4):e0124524
PloS one 2015;10(4):e0124524
Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1.
Reed M, Morris SH, Owczarczyk AB, Lukacs NW
Mucosal immunology 2015 Sep;8(5):1118-30
Mucosal immunology 2015 Sep;8(5):1118-30
Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion.
Liu L, Li CJ, Lu Y, Zong XG, Luo C, Sun J, Guo LJ
Scientific reports 2015 Sep 28;5:14474
Scientific reports 2015 Sep 28;5:14474
Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria.
Herpin A, Englberger E, Zehner M, Wacker R, Gessler M, Schartl M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Oct;29(10):4145-61
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Oct;29(10):4145-61
Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells.
Pukaß K, Goldbaum O, Richter-Landsberg C
Journal of neurochemistry 2015 Oct;135(1):194-205
Journal of neurochemistry 2015 Oct;135(1):194-205
Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma.
Pal I, Parida S, Prashanth Kumar BN, Banik P, Kumar Dey K, Chakraborty S, Bhutia SK, Mandal M
European journal of pharmacology 2015 Oct 15;765:217-27
European journal of pharmacology 2015 Oct 15;765:217-27
Xylitol induces cell death in lung cancer A549 cells by autophagy.
Park E, Park MH, Na HS, Chung J
Biotechnology letters 2015 May;37(5):983-90
Biotechnology letters 2015 May;37(5):983-90
NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice.
Roux C, Aligny C, Lesueur C, Girault V, Brunel V, Ramdani Y, Genty D, Driouich A, Laquerrière A, Marret S, Brasse-Lagnel C, Gonzalez BJ, Bekri S
Experimental neurology 2015 May;267:177-93
Experimental neurology 2015 May;267:177-93
A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in macrophages and zebrafish.
Mohanty S, Jagannathan L, Ganguli G, Padhi A, Roy D, Alaridah N, Saha P, Nongthomba U, Godaly G, Gopal RK, Banerjee S, Sonawane A
The Journal of biological chemistry 2015 May 22;290(21):13321-43
The Journal of biological chemistry 2015 May 22;290(21):13321-43
Autophagy in zebrafish.
Varga M, Fodor E, Vellai T
Methods (San Diego, Calif.) 2015 Mar;75:172-80
Methods (San Diego, Calif.) 2015 Mar;75:172-80
The generation of neutrophils in the bone marrow is controlled by autophagy.
Rožman S, Yousefi S, Oberson K, Kaufmann T, Benarafa C, Simon HU
Cell death and differentiation 2015 Mar;22(3):445-56
Cell death and differentiation 2015 Mar;22(3):445-56
Centrin2 regulates CP110 removal in primary cilium formation.
Prosser SL, Morrison CG
The Journal of cell biology 2015 Mar 16;208(6):693-701
The Journal of cell biology 2015 Mar 16;208(6):693-701
The relationship of autophagy defects to cartilage damage during joint aging in a mouse model.
Caramés B, Olmer M, Kiosses WB, Lotz MK
Arthritis & rheumatology (Hoboken, N.J.) 2015 Jun;67(6):1568-76
Arthritis & rheumatology (Hoboken, N.J.) 2015 Jun;67(6):1568-76
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.
Kaushik S, Cuervo AM
Nature cell biology 2015 Jun;17(6):759-70
Nature cell biology 2015 Jun;17(6):759-70
PKC theta and p38 MAPK activate the EBV lytic cycle through autophagy induction.
Gonnella R, Granato M, Farina A, Santarelli R, Faggioni A, Cirone M
Biochimica et biophysica acta 2015 Jul;1853(7):1586-95
Biochimica et biophysica acta 2015 Jul;1853(7):1586-95
Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy.
Xin W, Zhao X, Liu L, Xu Y, Li Z, Chen L, Wang X, Yi F, Wan Q
Biochemical and biophysical research communications 2015 Jul 31;463(3):364-9
Biochemical and biophysical research communications 2015 Jul 31;463(3):364-9
HIV-1 and morphine regulation of autophagy in microglia: limited interactions in the context of HIV-1 infection and opioid abuse.
El-Hage N, Rodriguez M, Dever SM, Masvekar RR, Gewirtz DA, Shacka JJ
Journal of virology 2015 Jan 15;89(2):1024-35
Journal of virology 2015 Jan 15;89(2):1024-35
The GTPase Rab26 links synaptic vesicles to the autophagy pathway.
Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, Chua JJ, Jahn R
eLife 2015 Feb 2;4:e05597
eLife 2015 Feb 2;4:e05597
In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy.
Lin HH
Chemical research in toxicology 2015 Feb 16;28(2):202-15
Chemical research in toxicology 2015 Feb 16;28(2):202-15
β-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy.
Yang S, Long LH, Li D, Zhang JK, Jin S, Wang F, Chen JG
Aging cell 2015 Dec;14(6):1024-33
Aging cell 2015 Dec;14(6):1024-33
Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.
Lee YH, Chen HY, Su LJ, Chueh PJ
Journal of agricultural and food chemistry 2015 Aug 26;63(33):7361-70
Journal of agricultural and food chemistry 2015 Aug 26;63(33):7361-70
MicroRNA-20a regulates autophagy related protein-ATG16L1 in hypoxia-induced osteoclast differentiation.
Sun KT, Chen MY, Tu MG, Wang IK, Chang SS, Li CY
Bone 2015 Apr;73:145-53
Bone 2015 Apr;73:145-53
The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.
Haldar AK, Piro AS, Pilla DM, Yamamoto M, Coers J
PloS one 2014;9(1):e86684
PloS one 2014;9(1):e86684
Growth factor receptor-bound protein 2 promotes autophagic removal of amyloid-β protein precursor intracellular domain overload in neuronal cells.
Roy K, Raychaudhuri M, Chakrabarti O, Mukhopadhyay D
Journal of Alzheimer's disease : JAD 2014;38(4):881-95
Journal of Alzheimer's disease : JAD 2014;38(4):881-95
Functional interactions between 17 β -estradiol and progesterone regulate autophagy during acini formation by bovine mammary epithelial cells in 3D cultures.
Zielniok K, Motyl T, Gajewska M
BioMed research international 2014;2014:382653
BioMed research international 2014;2014:382653
Distinct lysosome phenotypes influence inflammatory function in peritoneal and bone marrow-derived macrophages.
Weber K, Schilling JD
International journal of inflammation 2014;2014:154936
International journal of inflammation 2014;2014:154936
Role of VAMP3 and VAMP7 in the commitment of Yersinia pseudotuberculosis to LC3-associated pathways involving single- or double-membrane vacuoles.
Ligeon LA, Moreau K, Barois N, Bongiovanni A, Lacorre DA, Werkmeister E, Proux-Gillardeaux V, Galli T, Lafont F
Autophagy 2014 Sep;10(9):1588-602
Autophagy 2014 Sep;10(9):1588-602
Pine (Pinus morrisonicola Hayata) needle extracts sensitize GBM8901 human glioblastoma cells to temozolomide by downregulating autophagy and O(6)-methylguanine-DNA methyltransferase expression.
Liao CL, Chen CM, Chang YZ, Liu GY, Hung HC, Hsieh TY, Lin CL
Journal of agricultural and food chemistry 2014 Oct 29;62(43):10458-67
Journal of agricultural and food chemistry 2014 Oct 29;62(43):10458-67
Dynamic involvement of ATG5 in cellular stress responses.
Lin HH, Lin SM, Chung Y, Vonderfecht S, Camden JM, Flodby P, Borok Z, Limesand KH, Mizushima N, Ann DK
Cell death & disease 2014 Oct 23;5(10):e1478
Cell death & disease 2014 Oct 23;5(10):e1478
Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication.
Granato M, Santarelli R, Farina A, Gonnella R, Lotti LV, Faggioni A, Cirone M
Journal of virology 2014 Nov;88(21):12715-26
Journal of virology 2014 Nov;88(21):12715-26
Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.
Kao C, Chao A, Tsai CL, Chuang WC, Huang WP, Chen GC, Lin CY, Wang TH, Wang HS, Lai CH
Cell death & disease 2014 Nov 6;5(11):e1510
Cell death & disease 2014 Nov 6;5(11):e1510
Autophagy induced by tumor necrosis factor α mediates intrinsic apoptosis in trophoblastic cells.
Cha HH, Hwang JR, Kim HY, Choi SJ, Oh SY, Roh CR
Reproductive sciences (Thousand Oaks, Calif.) 2014 May;21(5):612-22
Reproductive sciences (Thousand Oaks, Calif.) 2014 May;21(5):612-22
Connexins modulate autophagosome biogenesis.
Bejarano E, Yuste A, Patel B, Stout RF Jr, Spray DC, Cuervo AM
Nature cell biology 2014 May;16(5):401-14
Nature cell biology 2014 May;16(5):401-14
FGF7/KGF regulates autophagy in keratinocytes: A novel dual role in the induction of both assembly and turnover of autophagosomes.
Belleudi F, Purpura V, Caputo S, Torrisi MR
Autophagy 2014 May;10(5):803-21
Autophagy 2014 May;10(5):803-21
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.
Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA
Cell 2014 May 8;157(4):882-896
Cell 2014 May 8;157(4):882-896
Autophagy enhances the replication of classical swine fever virus in vitro.
Pei J, Zhao M, Ye Z, Gou H, Wang J, Yi L, Dong X, Liu W, Luo Y, Liao M, Chen J
Autophagy 2014 Jan;10(1):93-110
Autophagy 2014 Jan;10(1):93-110
Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection.
Jabir MS, Ritchie ND, Li D, Bayes HK, Tourlomousis P, Puleston D, Lupton A, Hopkins L, Simon AK, Bryant C, Evans TJ
Cell host & microbe 2014 Feb 12;15(2):214-27
Cell host & microbe 2014 Feb 12;15(2):214-27
Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation.
Ciccia F, Accardo-Palumbo A, Rizzo A, Guggino G, Raimondo S, Giardina A, Cannizzaro A, Colbert RA, Alessandro R, Triolo G
Annals of the rheumatic diseases 2014 Aug;73(8):1566-74
Annals of the rheumatic diseases 2014 Aug;73(8):1566-74
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.
Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC, Von Hoff DD, Maitra A, Kimmelman AC
Cancer discovery 2014 Aug;4(8):905-13
Cancer discovery 2014 Aug;4(8):905-13
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Arid JM, Mouton S, Sebti Y, Duez H, Preau S, Remy-Jouet I, Zerimech F, Koussa M, Richard V, Neviere R, Edme JL, Lefebvre P, Staels B
Circulation 2014 Aug 12;130(7):554-64
Circulation 2014 Aug 12;130(7):554-64
Suppression of autophagic activation in the mouse uterus by estrogen and progesterone.
Choi S, Shin H, Song H, Lim HJ
The Journal of endocrinology 2014 Apr;221(1):39-50
The Journal of endocrinology 2014 Apr;221(1):39-50
Autophagy is required for zebrafish caudal fin regeneration.
Varga M, Sass M, Papp D, Takács-Vellai K, Kobolak J, Dinnyés A, Klionsky DJ, Vellai T
Cell death and differentiation 2014 Apr;21(4):547-56
Cell death and differentiation 2014 Apr;21(4):547-56
Dissection of autophagy in human platelets.
Feng W, Chang C, Luo D, Su H, Yu S, Hua W, Chen Z, Hu H, Liu W
Autophagy 2014 Apr;10(4):642-51
Autophagy 2014 Apr;10(4):642-51
Autophagy is essential for cardiac morphogenesis during vertebrate development.
Lee E, Koo Y, Ng A, Wei Y, Luby-Phelps K, Juraszek A, Xavier RJ, Cleaver O, Levine B, Amatruda JF
Autophagy 2014 Apr;10(4):572-87
Autophagy 2014 Apr;10(4):572-87
DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV.
Laforge M, Limou S, Harper F, Casartelli N, Rodrigues V, Silvestre R, Haloui H, Zagury JF, Senik A, Estaquier J
PLoS pathogens 2013;9(5):e1003328
PLoS pathogens 2013;9(5):e1003328
JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells.
Granato M, Santarelli R, Lotti LV, Di Renzo L, Gonnella R, Garufi A, Trivedi P, Frati L, D'Orazi G, Faggioni A, Cirone M
PloS one 2013;8(9):e75965
PloS one 2013;8(9):e75965
Adiponectin modulates oxidative stress-induced autophagy in cardiomyocytes.
Essick EE, Wilson RM, Pimentel DR, Shimano M, Baid S, Ouchi N, Sam F
PloS one 2013;8(7):e68697
PloS one 2013;8(7):e68697
Peroxisome proliferator-activated receptor δ agonist, HPP593, prevents renal necrosis under chronic ischemia.
Fedorova LV, Sodhi K, Gatto-Weis C, Puri N, Hinds TD Jr, Shapiro JI, Malhotra D
PloS one 2013;8(5):e64436
PloS one 2013;8(5):e64436
Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma.
Townsend KN, Spowart JE, Huwait H, Eshragh S, West NR, Elrick MA, Kalloger SE, Anglesio M, Watson PH, Huntsman DG, Lum JJ
PloS one 2013;8(12):e82406
PloS one 2013;8(12):e82406
Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.
Brennan GP, Jimenez-Mateos EM, McKiernan RC, Engel T, Tzivion G, Henshall DC
PloS one 2013;8(1):e54491
PloS one 2013;8(1):e54491
Autophagy proteins regulate ERK phosphorylation.
Martinez-Lopez N, Athonvarangkul D, Mishall P, Sahu S, Singh R
Nature communications 2013;4:2799
Nature communications 2013;4:2799
The anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in HER2-positive breast cancer.
Cufí S, Vazquez-Martin A, Oliveras-Ferraros C, Corominas-Faja B, Cuyàs E, López-Bonet E, Martin-Castillo B, Joven J, Menendez JA
Scientific reports 2013;3:2469
Scientific reports 2013;3:2469
Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development.
Martinez-Lopez N, Athonvarangkul D, Sahu S, Coletto L, Zong H, Bastie CC, Pessin JE, Schwartz GJ, Singh R
EMBO reports 2013 Sep;14(9):795-803
EMBO reports 2013 Sep;14(9):795-803
Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.
Lucin KM, O'Brien CE, Bieri G, Czirr E, Mosher KI, Abbey RJ, Mastroeni DF, Rogers J, Spencer B, Masliah E, Wyss-Coray T
Neuron 2013 Sep 4;79(5):873-86
Neuron 2013 Sep 4;79(5):873-86
Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory syncytial virus infection.
Reed M, Morris SH, Jang S, Mukherjee S, Yue Z, Lukacs NW
Journal of immunology (Baltimore, Md. : 1950) 2013 Sep 1;191(5):2526-37
Journal of immunology (Baltimore, Md. : 1950) 2013 Sep 1;191(5):2526-37
Deletion of ATG5 shows a role of autophagy in salivary homeostatic control.
Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH
Journal of dental research 2013 Oct;92(10):911-7
Journal of dental research 2013 Oct;92(10):911-7
Epigenetic regulation of autophagy by the methyltransferase G9a.
Artal-Martinez de Narvajas A, Gomez TS, Zhang JS, Mann AO, Taoda Y, Gorman JA, Herreros-Villanueva M, Gress TM, Ellenrieder V, Bujanda L, Kim DH, Kozikowski AP, Koenig A, Billadeau DD
Molecular and cellular biology 2013 Oct;33(20):3983-93
Molecular and cellular biology 2013 Oct;33(20):3983-93
Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells.
Hollomon MG, Gordon N, Santiago-O'Farrill JM, Kleinerman ES
BMC cancer 2013 Oct 26;13:500
BMC cancer 2013 Oct 26;13:500
Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury.
Yen YT, Yang HR, Lo HC, Hsieh YC, Tsai SC, Hong CW, Hsieh CH
Surgery 2013 May;153(5):689-98
Surgery 2013 May;153(5):689-98
Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation.
Notte A, Ninane N, Arnould T, Michiels C
Cell death & disease 2013 May 16;4:e638
Cell death & disease 2013 May 16;4:e638
Inhibiting autophagy potentiates the anticancer activity of IFN1@/IFNα in chronic myeloid leukemia cells.
Zhu S, Cao L, Yu Y, Yang L, Yang M, Liu K, Huang J, Kang R, Livesey KM, Tang D
Autophagy 2013 Mar;9(3):317-27
Autophagy 2013 Mar;9(3):317-27
Identification of autophagic vacuoles and regulators of autophagy in villous trophoblast from normal term pregnancies and in fetal growth restriction.
Curtis S, Jones CJ, Garrod A, Hulme CH, Heazell AE
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2013 Mar;26(4):339-46
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2013 Mar;26(4):339-46
Autophagy protects the retina from light-induced degeneration.
Chen Y, Sawada O, Kohno H, Le YZ, Subauste C, Maeda T, Maeda A
The Journal of biological chemistry 2013 Mar 15;288(11):7506-18
The Journal of biological chemistry 2013 Mar 15;288(11):7506-18
Intestinal epithelial autophagy is essential for host defense against invasive bacteria.
Benjamin JL, Sumpter R Jr, Levine B, Hooper LV
Cell host & microbe 2013 Jun 12;13(6):723-34
Cell host & microbe 2013 Jun 12;13(6):723-34
Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation.
Amir M, Zhao E, Fontana L, Rosenberg H, Tanaka K, Gao G, Czaja MJ
Cell death and differentiation 2013 Jul;20(7):878-87
Cell death and differentiation 2013 Jul;20(7):878-87
Autophagy is required for IL-2-mediated fibroblast growth.
Kang R, Tang D, Lotze MT, Zeh Iii HJ
Experimental cell research 2013 Feb 15;319(4):556-65
Experimental cell research 2013 Feb 15;319(4):556-65
Identification of a candidate therapeutic autophagy-inducing peptide.
Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW, Helms JB, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, Levine B
Nature 2013 Feb 14;494(7436):201-6
Nature 2013 Feb 14;494(7436):201-6
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia.
Liu Y, Shoji-Kawata S, Sumpter RM Jr, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 17;110(51):20364-71
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 17;110(51):20364-71
The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.
Sorrentino V, Nelson JK, Maspero E, Marques ARA, Scheer L, Polo S, Zelcer N
Journal of lipid research 2013 Aug;54(8):2174-2184
Journal of lipid research 2013 Aug;54(8):2174-2184
Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation.
Zhang C, He Y, Okutsu M, Ong LC, Jin Y, Zheng L, Chow P, Yu S, Zhang M, Yan Z
American journal of physiology. Endocrinology and metabolism 2013 Aug 15;305(4):E530-9
American journal of physiology. Endocrinology and metabolism 2013 Aug 15;305(4):E530-9
Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.
Fu M, St-Pierre P, Shankar J, Wang PT, Joshi B, Nabi IR
Molecular biology of the cell 2013 Apr;24(8):1153-62
Molecular biology of the cell 2013 Apr;24(8):1153-62
Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
Long L, Yang X, Southwood M, Lu J, Marciniak SJ, Dunmore BJ, Morrell NW
Circulation research 2013 Apr 12;112(8):1159-70
Circulation research 2013 Apr 12;112(8):1159-70
Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress.
Shi JM, Bai LL, Zhang DM, Yiu A, Yin ZQ, Han WL, Liu JS, Li Y, Fu DY, Ye WC
Biochemical pharmacology 2013 Apr 1;85(7):913-26
Biochemical pharmacology 2013 Apr 1;85(7):913-26
Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure.
Garcia AG, Wilson RM, Heo J, Murthy NR, Baid S, Ouchi N, Sam F
American journal of physiology. Heart and circulatory physiology 2012 Sep 1;303(5):H587-96
American journal of physiology. Heart and circulatory physiology 2012 Sep 1;303(5):H587-96
RNase L triggers autophagy in response to viral infections.
Chakrabarti A, Ghosh PK, Banerjee S, Gaughan C, Silverman RH
Journal of virology 2012 Oct;86(20):11311-21
Journal of virology 2012 Oct;86(20):11311-21
Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy.
Zang Y, Thomas SM, Chan ET, Kirk CJ, Freilino ML, DeLancey HM, Grandis JR, Li C, Johnson DE
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Oct 15;18(20):5639-49
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Oct 15;18(20):5639-49
The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.
Kang R, Loux T, Tang D, Schapiro NE, Vernon P, Livesey KM, Krasinskas A, Lotze MT, Zeh HJ 3rd
Proceedings of the National Academy of Sciences of the United States of America 2012 May 1;109(18):7031-6
Proceedings of the National Academy of Sciences of the United States of America 2012 May 1;109(18):7031-6
Induction of autophagy is essential for monocyte-macrophage differentiation.
Zhang Y, Morgan MJ, Chen K, Choksi S, Liu ZG
Blood 2012 Mar 22;119(12):2895-905
Blood 2012 Mar 22;119(12):2895-905
Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice.
Sharara-Chami RI, Zhou Y, Ebert S, Pacak K, Ozcan U, Majzoub JA
The international journal of biochemistry & cell biology 2012 Jun;44(6):905-13
The international journal of biochemistry & cell biology 2012 Jun;44(6):905-13
Age-related oxidative stress compromises endosomal proteostasis.
Cannizzo ES, Clement CC, Morozova K, Valdor R, Kaushik S, Almeida LN, Follo C, Sahu R, Cuervo AM, Macian F, Santambrogio L
Cell reports 2012 Jul 26;2(1):136-49
Cell reports 2012 Jul 26;2(1):136-49
β-Elemene induces apoptosis as well as protective autophagy in human non-small-cell lung cancer A549 cells.
Liu J, Hu XJ, Jin B, Qu XJ, Hou KZ, Liu YP
The Journal of pharmacy and pharmacology 2012 Jan;64(1):146-53
The Journal of pharmacy and pharmacology 2012 Jan;64(1):146-53
IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux.
Lee H, Noh JY, Oh Y, Kim Y, Chang JW, Chung CW, Lee ST, Kim M, Ryu H, Jung YK
Human molecular genetics 2012 Jan 1;21(1):101-14
Human molecular genetics 2012 Jan 1;21(1):101-14
Autophagy is involved in the early step of Japanese encephalitis virus infection.
Li JK, Liang JJ, Liao CL, Lin YL
Microbes and infection 2012 Feb;14(2):159-68
Microbes and infection 2012 Feb;14(2):159-68
Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells.
Yu Y, Yang L, Zhao M, Zhu S, Kang R, Vernon P, Tang D, Cao L
Leukemia 2012 Aug;26(8):1752-60
Leukemia 2012 Aug;26(8):1752-60
Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells.
Sandilands E, Serrels B, Wilkinson S, Frame MC
EMBO reports 2012 Aug;13(8):733-40
EMBO reports 2012 Aug;13(8):733-40
Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease.
Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K
Oncoimmunology 2012 Aug 1;1(5):630-641
Oncoimmunology 2012 Aug 1;1(5):630-641
Autophagy links inflammasomes to atherosclerotic progression.
Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, Semenkovich CF
Cell metabolism 2012 Apr 4;15(4):534-44
Cell metabolism 2012 Apr 4;15(4):534-44
Autophagy positively regulates the CD44(+) CD24(-/low) breast cancer stem-like phenotype.
Cufí S, Vazquez-Martin A, Oliveras-Ferraros C, Martin-Castillo B, Vellon L, Menendez JA
Cell cycle (Georgetown, Tex.) 2011 Nov 15;10(22):3871-85
Cell cycle (Georgetown, Tex.) 2011 Nov 15;10(22):3871-85
Autophagy regulates embryonic survival during delayed implantation.
Lee JE, Oh HA, Song H, Jun JH, Roh CR, Xie H, Dey SK, Lim HJ
Endocrinology 2011 May;152(5):2067-75
Endocrinology 2011 May;152(5):2067-75
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity.
Dash R, Azab B, Quinn BA, Shen X, Wang XY, Das SK, Rahmani M, Wei J, Hedvat M, Dent P, Dmitriev IP, Curiel DT, Grant S, Wu B, Stebbins JL, Pellecchia M, Reed JC, Sarkar D, Fisher PB
Proceedings of the National Academy of Sciences of the United States of America 2011 May 24;108(21):8785-90
Proceedings of the National Academy of Sciences of the United States of America 2011 May 24;108(21):8785-90
Silica nanoconstruct cellular toleration threshold in vitro.
Herd HL, Malugin A, Ghandehari H
Journal of controlled release : official journal of the Controlled Release Society 2011 Jul 15;153(1):40-8
Journal of controlled release : official journal of the Controlled Release Society 2011 Jul 15;153(1):40-8
Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.
Brady OA, Meng P, Zheng Y, Mao Y, Hu F
Journal of neurochemistry 2011 Jan;116(2):248-59
Journal of neurochemistry 2011 Jan;116(2):248-59
PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase.
Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, Cuervo AM, Perez-Soler R
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Aug 15;17(16):5353-66
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 Aug 15;17(16):5353-66
Calcipotriol induces autophagy in HeLa cells and keratinocytes.
Wang RC, Levine B
The Journal of investigative dermatology 2011 Apr;131(4):990-3
The Journal of investigative dermatology 2011 Apr;131(4):990-3
Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival.
Elgendy M, Sheridan C, Brumatti G, Martin SJ
Molecular cell 2011 Apr 8;42(1):23-35
Molecular cell 2011 Apr 8;42(1):23-35
Rosetta FlexPepDock ab-initio: simultaneous folding, docking and refinement of peptides onto their receptors.
Raveh B, London N, Zimmerman L, Schueler-Furman O
PloS one 2011 Apr 29;6(4):e18934
PloS one 2011 Apr 29;6(4):e18934
Entrapment of intracytosolic bacteria by septin cage-like structures.
Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, Cossart P
Cell host & microbe 2010 Nov 18;8(5):433-44
Cell host & microbe 2010 Nov 18;8(5):433-44
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.
Travassos LH, Carneiro LA, Ramjeet M, Hussey S, Kim YG, Magalhães JG, Yuan L, Soares F, Chea E, Le Bourhis L, Boneca IG, Allaoui A, Jones NL, Nuñez G, Girardin SE, Philpott DJ
Nature immunology 2010 Jan;11(1):55-62
Nature immunology 2010 Jan;11(1):55-62
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation.
Fujimoto K, Hanson PT, Tran H, Ford EL, Han Z, Johnson JD, Schmidt RE, Green KG, Wice BM, Polonsky KS
The Journal of biological chemistry 2009 Oct 2;284(40):27664-73
The Journal of biological chemistry 2009 Oct 2;284(40):27664-73
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection.
English L, Chemali M, Duron J, Rondeau C, Laplante A, Gingras D, Alexander D, Leib D, Norbury C, Lippé R, Desjardins M
Nature immunology 2009 May;10(5):480-7
Nature immunology 2009 May;10(5):480-7
Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia.
Lee JA, Gao FB
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jul 1;29(26):8506-11
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 Jul 1;29(26):8506-11
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.
Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, Kishi C, Kc W, Carrero JA, Hunt S, Stone CD, Brunt EM, Xavier RJ, Sleckman BP, Li E, Mizushima N, Stappenbeck TS, Virgin HW 4th
Nature 2008 Nov 13;456(7219):259-63
Nature 2008 Nov 13;456(7219):259-63
Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus.
Wang Y, Singh R, Massey AC, Kane SS, Kaushik S, Grant T, Xiang Y, Cuervo AM, Czaja MJ
The Journal of biological chemistry 2008 Feb 22;283(8):4766-77
The Journal of biological chemistry 2008 Feb 22;283(8):4766-77
Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death.
Pyo JO, Nah J, Kim HJ, Lee HJ, Heo J, Lee H, Jung YK
Autophagy 2008 Apr;4(3):315-21
Autophagy 2008 Apr;4(3):315-21
Compensatory activation of ERK1/2 in Atg5-deficient mouse embryo fibroblasts suppresses oxidative stress-induced cell death.
Pyo JO, Nah J, Kim HJ, Lee HJ, Heo J, Lee H, Jung YK
Autophagy 2008 Apr;4(3):315-21
Autophagy 2008 Apr;4(3):315-21
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Simple Western: ATG5 Antibody [NB110-53818] - Simple Western lane view shows a specific band for ATG5 in 0.5 mg/mL of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATG5 Antibody [NB110-53818] - Western blot analysis in mouse wildtype ES cell lysate (Lane 1) using NB110-53818. Lane 2 is a mouse ATG5 KO ES cell lysate (negative control). Atg5-/- ES cells from Dr. Noboru Mizushima [Mizushima, N. et al. J. Cell Biol. 152 (2001)] Photo courtesy of Dr. Beth Levine, UT Southwestern Medical Center.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATG5 Antibody [NB110-53818] - Western blot analysis of total protein from Human HeLa and A431 and Mouse MEF cells. Lysates were separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/mL anti-ATG5 in 1% non-fat milk in TBST and detected with an anti-rabbit HRP secondary antibody using chemiluminescence.
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATG5 Antibody [NB110-53818] - ERK phosphorylation in Atg5-/-cells depends on nutrient availability. Serum-deprived Atg5-/- MEFs display decreased ERK and p90RSK phosphorylation. Immunoblots for the indicated proteins in total lysates from 2 h serum-deprived WT and Atg5-/- MEFs. The bars represent mean+/-s.e.m. *P
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATG5 Antibody [NB110-53818] - IFN-gamma increased rates of autophagy in primary BMECs in vitro. BMECs were treated with IFN-gamma at 2.5, 5, 10 or 20 ng/mL. At the end of the treatment, levels of MAP1LC3, ATG12-ATG5, SQSTM1/p62 and GAPDH were analyzed using Western blot analysis with specific antibodies as described in the Materials and Methods section. The data represent the mean+/-S.E.M. of three independent experiments. Error bars are +/-S.E.M. One-way ANOVA; *P
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: ATG5 Antibody [NB110-53818] - Immunohistochemistry analysis of mouse intestine using DAB with hematoxylin counterstain.
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ATG5 Antibody [NB110-53818] - Immunohistochemistry analysis of mouse knee. IHC-P image submitted by a verified customer review.
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: ATG5 Antibody [NB110-53818] - Immunohistochemistry analysis of human liver hepatocytes at 2.5 ug/mL. 40X magnification.
