Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 13978-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13978-1-AP, RRID:AB_2186546
- Product name
- SEC63 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SEC63 antibody (Cat. #13978-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references ER entry pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal GPI-attachment sequence.
Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes.
Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.
Hirata T, Yang J, Tomida S, Tokoro Y, Kinoshita T, Fujita M, Kizuka Y
The Journal of biological chemistry 2022 Oct;298(10):102444
The Journal of biological chemistry 2022 Oct;298(10):102444
Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes.
Hassan H, Tian X, Inoue K, Chai N, Liu C, Soda K, Moeckel G, Tufro A, Lee AH, Somlo S, Fedeles S, Ishibe S
Journal of the American Society of Nephrology : JASN 2016 Apr;27(4):1055-65
Journal of the American Society of Nephrology : JASN 2016 Apr;27(4):1055-65
Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
Fedeles SV, So JS, Shrikhande A, Lee SH, Gallagher AR, Barkauskas CE, Somlo S, Lee AH
The Journal of clinical investigation 2015 May;125(5):1955-67
The Journal of clinical investigation 2015 May;125(5):1955-67
Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.
Conti BJ, Devaraneni PK, Yang Z, David LL, Skach WR
Molecular cell 2015 Apr 16;58(2):269-83
Molecular cell 2015 Apr 16;58(2):269-83
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Supportive validation
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- Proteintech Group (provider)
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- Experimental details
- The SEC63 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SEC63. This antibody recognizes human, mouse, rat antigen. The SEC63 antibody has been validated for the following applications: ELISA, WB analysis.