MAL

The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]

Description

Mal, T cell differentiation protein

Tissue specificity

Tissue enhanced (esophagus, vagina)

Subcell location

Golgi apparatus, Centrosome

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

2 (95025677 - 95053992)

Ensembl ID

ENSG00000172005  (ver. 103.38)

Orthologs

Mouse Mal: ENSMUSG00000027375

UniProt

P21145

neXtProt

NX_P21145

Human splice variants
Mouse splice variants

Protein structure