BS7042
antibody from Bioworld Technology, Inc
Targeting: KLK8
HNP, neuropsin, ovasin, PRSS19, TADG14
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS7042 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- Cleaved KLK8 (V33) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 11-60 of Human KLK8.
- Description
- Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Kallikrein-8 (KLK8), also called neuropsin precursor, ovasin or serine protease 19, is a 260 amino acid secreted protein involved in hippocampal plasticity. Two isoforms exist for this protein. Isoform 1 is the primary form of KLK8 found predominantly in the pancreas. Isoform 2 contains an additional 46 amino acids after amino acid 23 and is predominantly expressed in adult brain and hippocampus. Isoform 2 is not common to the mouse homolog or other primate homologs. In humans, the T to A mutation (c.71-127T>A) leads to the splice variant seen in the human brain. Both isoforms are detected in fetal brain and placenta. In some cancer cells, KLK8 expression can suppress tumor cell invasiveness and lead to a favorable clinical outcome.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of Cleaved-KLK8 (V33) pAb at 1:500 dilutionLane1:HEK293T cell lysateLane2:Mouse kidney tissue lysateLane3:Rat kidney tissue lysate