Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
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Validation data
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- Product number
- NB100-2582 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-2582, RRID:AB_2196402
- Product name
- Rabbit Polyclonal Spt6 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Chicken/Avian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 0.2 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness.
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.
MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation.
RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing.
Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence.
The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.
A role for the RNA pol II-associated PAF complex in AID-induced immune diversification.
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV.
Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan NL, Wang R, Wang YJ, Semenza GL
The Journal of clinical investigation 2020 Jul 27;
The Journal of clinical investigation 2020 Jul 27;
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.
Chirackal Manavalan AP, Pilarova K, Kluge M, Bartholomeeusen K, Rajecky M, Oppelt J, Khirsariya P, Paruch K, Krejci L, Friedel CC, Blazek D
EMBO reports 2019 Sep;20(9):e47592
EMBO reports 2019 Sep;20(9):e47592
MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation.
Baluapuri A, Hofstetter J, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E
Molecular cell 2019 May 16;74(4):674-687.e11
Molecular cell 2019 May 16;74(4):674-687.e11
RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing.
Nojima T, Rebelo K, Gomes T, Grosso AR, Proudfoot NJ, Carmo-Fonseca M
Molecular cell 2018 Oct 18;72(2):369-379.e4
Molecular cell 2018 Oct 18;72(2):369-379.e4
Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence.
Nojima T, Tellier M, Foxwell J, Ribeiro de Almeida C, Tan-Wong SM, Dhir S, Dujardin G, Dhir A, Murphy S, Proudfoot NJ
Molecular cell 2018 Dec 20;72(6):970-984.e7
Molecular cell 2018 Dec 20;72(6):970-984.e7
The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.
Wang AH, Juan AH, Ko KD, Tsai PF, Zare H, Dell'Orso S, Sartorelli V
Molecular cell 2017 Oct 19;68(2):398-413.e6
Molecular cell 2017 Oct 19;68(2):398-413.e6
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.
Wang AH, Zare H, Mousavi K, Wang C, Moravec CE, Sirotkin HI, Ge K, Gutierrez-Cruz G, Sartorelli V
The EMBO journal 2013 Apr 17;32(8):1075-86
The EMBO journal 2013 Apr 17;32(8):1075-86
A role for the RNA pol II-associated PAF complex in AID-induced immune diversification.
Willmann KL, Milosevic S, Pauklin S, Schmitz KM, Rangam G, Simon MT, Maslen S, Skehel M, Robert I, Heyer V, Schiavo E, Reina-San-Martin B, Petersen-Mahrt SK
The Journal of experimental medicine 2012 Oct 22;209(11):2099-111
The Journal of experimental medicine 2012 Oct 22;209(11):2099-111
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Chen S, Ma J, Wu F, Xiong LJ, Ma H, Xu W, Lv R, Li X, Villen J, Gygi SP, Liu XS, Shi Y
Genes & development 2012 Jun 15;26(12):1364-75
Genes & development 2012 Jun 15;26(12):1364-75
Binding of the human cytomegalovirus (HCMV) tegument protein UL69 to UAP56/URH49 is not required for efficient replication of HCMV.
Kronemann D, Hagemeier SR, Cygnar D, Phillips S, Bresnahan WA
Journal of virology 2010 Sep;84(18):9649-54
Journal of virology 2010 Sep;84(18):9649-54
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Spt6 Antibody [NB100-2582] - Detection of Human Spt6 on HeLa whole cell lysate using NB100-2582. Spt6 was also immunoprecipitated by another rabbit anti-Spt6 antibody.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Spt6 Antibody [NB100-2582] - siRNA knockdown to confirm the specificity of Spt6 antibody (NB100-2582) in C2C12 myoblasts, WB: 1:2000 dilution. 20ug whole cell lysate. Image from verified customer review.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Spt6 Antibody [NB100-2582] - Sections of human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti- SUPT6H used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB