Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7987 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- HINFP polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human HINFP.
- Description
- HiNF-P is a critial transcription factor which is necessay for E2F-independent activation of the Histone H4 multigene family. HiNF-P associates with conserved H4 cell cycle regulatory sequences in vivo. Antisense inhibition of HiNF-P reduces endogenous Histone H4 gene expression. HiNF-P utilizes NPAT/p220, a substrate of the cyclin E/cyclin-dependent kinase 2 (CDK2) kinase complex, as a crucial coactivator to amplify Histone H4 gene transcription. The biological role of HiNF-P is reflected by impeded cell cycle progression into S phase upon antisense-mediated reduction of HiNF-P levels. Research indicates that HiNF-P is the key link in a linear signaling pathway that is initiated with the growth factor-dependent induction of cyclin E/ CDK2 kinase activity at the restriction point and culminates in the activation of Histone H4 genes through HiNF-P at the G1/S phase transition.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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