QTRT2

This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Description

Queuine tRNA-ribosyltransferase accessory subunit 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Intermediate filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (114005833 - 114088422)

Ensembl ID

ENSG00000151576  (ver. 103.38)

Orthologs

Mouse Qtrt2: ENSMUSG00000022704

UniProt

Q9H974

neXtProt

NX_Q9H974

Human splice variants
Mouse splice variants

Protein structure