BS9176

antibody from Bioworld Technology, Inc
Targeting: KCNJ4 HIR, hIRK2, HRK1, IRK3, Kir2.3
Provider product page for BS9176
Western blot

Antibody data

Product number
BS9176 - Provider product page
Provider
Bioworld Technology, Inc
Product name
KIR2.3 (E285) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 250-300 of Human KIR2.3.
Description
The KIR2 subunit family includes 2.1, 2.2, 2.3 and 2.4. Unlike G-protein coupled KIR3 subunits, KIR2.1 requires both phosphorylation by PKA and ATP hydrolysis for functional activity. KIR2.1 is expressed in the superior and inferior collicula and the pontine region of the brain, where it moderates synaptic transmission, like many other potassium channels. In the placenta, KIR2.1 is expressed throughout gestation in cytotrophoblast cells. In the kidney, KIR2.1 colocalizes with KIR5.1 in the proximal tubule. KIR2.1, 2.2 and 2.3 associate with the membrane-associated guanylate kinase synapse-associated protein 97 in the cerebellum and heart. Phosphorylation of KIR2.2 by protein kinase A inhibits the associates with SAP97. Arachidonic acid increases current amplitude in KIR2.3 activity but does not affect the activity of KIR2.1, 2.2 or 2.4.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
KCNJ4 protein structure - BS9176 shown in red.