Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS8299 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- HGD polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human HGD.
- Description
- HGD (homogentisate 1,2-dioxygenase), also known as HGO (homogentisate oxygenase), is a 445 amino acid protein that belongs to the homogentisate dioxygenase family and is involved in the pathway of amino acid degradation. Expressed at high levels in kidney, colon, liver, prostate and small intestine, HGD uses iron as a cofactor to catalyze the oxygen-dependent conversion of homogentisate to 4-maleylacetoacetate, a reaction that is the fourth step in the creation of L-phenylalanine from fumarate and acetoacetic acid. Defects in the gene encoding HGD are the cause of alkaptonuria (AKU), an autosomal recessive disorder that is characterized by urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues and spine arthritis.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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