L3MBTL3

This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma. [provided by RefSeq, Oct 2016]

Description

L3MBTL histone methyl-lysine binding protein 3

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Nucleoli rim

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (130013699 - 130141449)

Ensembl ID

ENSG00000198945  (ver. 103.38)

Orthologs

Mouse L3mbtl3: ENSMUSG00000039089

UniProt

Q96JM7

neXtProt

NX_Q96JM7

Human splice variants
Mouse splice variants

Protein structure