338703

antibody from BioLegend
Targeting: LILRB2 CD85d, ILT4, LIR-2, LIR2, MIR-10, MIR10
Provider product page for 338703
Flow cytometry
Functional assay

Antibody data

Product number
338703 - Provider product page
Provider
BioLegend
Product name
LEAF™ Purified anti-human CD85d (ILT4) [42D1]
Antibody type
Monoclonal
Antigen
CD85d (ILT4)
Description
CD85 is a group of Ig superfamily tansmembrane glycoproteins called Ig-Like Transcripts (ILTs) or Leukocyte Immunoglobulin-like Receptors (LIRs). It is composed of both activating and inhibitory isoforms. The activating subset of ILTs is characterized by containing short cytoplasmic domains and positively charged arginine residues, while the inhibitory isoforms display long cytoplasmic tails containing ITIM motifs. CD85d is a 95kD inhibitory receptor, also known as ILT4, LIR2, or MIR10. ILT4 is expressed on the surface of monocytes/macrophages, and dendritic cells. ILT4 acts as an inhibitory receptor through recruitment of SHP-1 and SHP-2 protein tyrosine phosphatases. The ligands of ILT4 are HLA-A, -B and nonclassical MHC-I molecule HLA-G1.
Reactivity
Human
Host
Rat
Conjugate
Unconjugated
Isotype
IgG
Vial size
50 µg
Concentration
1 mg/ml
Storage
The antibody solution should be stored undiluted at 4 °C.  This LEAF™ solution contains no preservative; handle under aseptic conditions.
LILRB2 protein structure - 338703 shown in red.