GIMAP1

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene is thought to be involved in the differentiation of T helper (Th) cells of the Th1 lineage, and the related mouse gene has been shown to be critical for the development of mature B and T lymphocytes. Read-through transcription exists between this gene and the downstream GIMAP5 (GTPase, IMAP family member 5) gene. [provided by RefSeq, Dec 2010]

Description

GTPase, IMAP family member 1

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Endoplasmic reticulum

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (150716606 - 150724284)

Ensembl ID

ENSG00000213203  (ver. 103.38)

Orthologs

Mouse Gimap1: ENSMUSG00000090019

UniProt

Q8WWP7

neXtProt

NX_Q8WWP7

Human splice variants
Mouse splice variants

Protein structure