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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Flow cytometry [1]
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- Product number
- 50-9813-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- GP6 Monoclonal Antibody (HY101), eFluor™ 660, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The HY101 monoclonal antibody reacts with the glycoprotein VI (GPVI), a 62-kDa type-I transmembrane glycoprotein that is expressed on mature megakaryotes and platelets. GPVI associates with the Fc receptor (FcR) gamma-chain to form a high affinity receptor for collagen. GPVI has also been reported to bind convulxin (Cvx). Phosphorylation of the ITAMs present on the FcR gamma-chain leads to recruitment of Src family kinases and activation of downstream signal transduction. GPVI has been reported to play a critical role in platelet activation and aggregation.
- Antibody clone number
- HY101
- Concentration
- 5 µL/Test
Submitted references Shear-induced platelet receptor shedding by non-physiological high shear stress with short exposure time: glycoprotein IbĪ± and glycoprotein VI.
Chen Z, Mondal NK, Ding J, Gao J, Griffith BP, Wu ZJ
Thrombosis research 2015 Apr;135(4):692-8
Thrombosis research 2015 Apr;135(4):692-8
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Staining of normal human platelets with Anti-Human CD41a PE (Product # 12-0419-42) and Mouse IgG1 K Isotype Control eFluor® 660 (Product # 50-4714-82) (left) or Anti-Human Glycoprotein VI eFluor® 660 (right). Total viable cells were used for analysis.
