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Cell line expression
Protein structure
DCPS
Decapping enzyme, scavengerHINT-5, HINT5, HSL1, HSPC015
This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]
Top validated antibodies |
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| LSBio |  LS-C133735 |
Monoclonal |
WB
EL
ICC
IHC
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| Atlas Antibodies | HPA039632 |
2 references | Polyclonal |
WB
ICC
IHC
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| Novus Biologicals | H00028960-M02 |
Monoclonal |
WB
EL
ICC
IHC
|
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| Abnova Corporation | H00028960-M02 |
Monoclonal |
WB
EL
ICC
IHC
|
||
| Invitrogen Antibodies | H00028960-M02 |
Monoclonal |
WB
EL
ICC
IHC
|
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