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- Antigen structure
- References [5]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN952805 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone 1 (HSPBP1) (N-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- Other
- Reactivity
- Human
- Host
- Rabbit
- Vial size
- 0.1 mg
Submitted references Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces.
HspBP1 levels are elevated in breast tumor tissue and inversely related to tumor aggressiveness.
Extracellular HspBP1 and Hsp72 synergistically activate epidermal growth factor receptor.
HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease.
Lamina-associated polypeptide 2alpha forms complexes with heat shock proteins Hsp70 and Hsc70 in vivo.
Graner MW, Raynes DA, Bigner DD, Guerriero V
Cancer science 2009 Oct;100(10):1870-9
Cancer science 2009 Oct;100(10):1870-9
HspBP1 levels are elevated in breast tumor tissue and inversely related to tumor aggressiveness.
Souza AP, Albuquerque C, Torronteguy C, Frasson A, Maito F, Pereira L, Duval da Silva V, Zerwes F, Raynes D, Guerriero V, Bonorino C
Cell stress & chaperones 2009 May;14(3):301-10
Cell stress & chaperones 2009 May;14(3):301-10
Extracellular HspBP1 and Hsp72 synergistically activate epidermal growth factor receptor.
Evdonin A, Kinev A, Tsupkina N, Guerriero V, Raynes DA, Medvedeva N
Biology of the cell / under the auspices of the European Cell Biology Organization 2009 Jun;101(6):351-60
Biology of the cell / under the auspices of the European Cell Biology Organization 2009 Jun;101(6):351-60
HSP70 interacting protein prevents the accumulation of inclusions in polyglutamine disease.
Howarth JL, Glover CP, Uney JB
Journal of neurochemistry 2009 Feb;108(4):945-951
Journal of neurochemistry 2009 Feb;108(4):945-951
Lamina-associated polypeptide 2alpha forms complexes with heat shock proteins Hsp70 and Hsc70 in vivo.
Snyers L, Schöfer C
Biochemical and biophysical research communications 2008 Apr 11;368(3):767-71
Biochemical and biophysical research communications 2008 Apr 11;368(3):767-71
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of HSPBP1 Antibody (N-term) Cat.-No AP52122PU-N in Jurkat cell line lysates (35ug/lane). This demonstrates the HSPBP1 antibody detected the HSPBP1 protein (arrow).
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue reacted with HSPBP1 Antibody (N-term) Cat.-No AP52122PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining.
