LRP8

This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

Description

LDL receptor related protein 8

Tissue specificity

Tissue enhanced (testis, thyroid gland)

Predicted location

Intracellular, Membrane, Secreted in other tissues

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (53242364 - 53328469)

Ensembl ID

ENSG00000157193  (ver. 103.38)

Orthologs

Mouse Lrp8: ENSMUSG00000028613

UniProt

Q14114

neXtProt

NX_Q14114

Human splice variants
Mouse splice variants

Protein structure