NLRP11

This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]

Description

NLR family pyrin domain containing 11

Tissue specificity

Tissue enhanced (epididymis, liver)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

19 (55785397 - 55836800)

Ensembl ID

ENSG00000179873  (ver. 103.38)

Orthologs

-

UniProt

P59045

neXtProt

NX_P59045

Human splice variants

Protein structure