Tissue expression
Cell line expression
Protein structure
NLRP4
NLR family pyrin domain containing 4CLR19.5, CT58, FLJ32126, NALP4, PAN2, PYPAF4, RNH2
The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]
Top validated antibodies |
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Novus Biologicals | NB100-56156 | 3 references | Polyclonal |
WB
IP
IHC
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antibodies-online | ABIN783705 | 2 references | Polyclonal |
WB
EL |
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Biorbyt | orb446365 | Polyclonal |
WB
EL
IHC
|
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OriGene | TA337216 | Polyclonal |
WB
ICC |
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Boster Biological Technology | A08477 | Polyclonal |
WB
EL |
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