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LearnTissue expression
Cell line expression
Protein structure
LATS1
Large tumor suppressor kinase 1WARTS
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Top validated antibodies |
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| Proteintech Group |  17049-1-AP |
21 references | Polyclonal |
WB
EL
IHC
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| Boster Biological Technology | A01051-2 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| antibodies-online | ABIN2841200 |
6 references | Polyclonal |
WB
IHC
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| Novus Biologicals | NB200-197 |
6 references | Polyclonal |
WB
IP
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| Invitrogen Antibodies | PA5-95564 |
Polyclonal |
WB
EL
IHC
FC
|
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