RAET1G

This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]

Description

Retinoic acid early transcript 1G

Tissue specificity

Tissue enhanced (adrenal gland, esophagus)

Subcell location

Vesicles, Plasma membrane

Predicted location

Membrane, Secreted - unknown location

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins

Chromosome

6 (149916878 - 149923121)

Ensembl ID

ENSG00000203722  (ver. 103.38)

Orthologs

-

UniProt

Q6H3X3

neXtProt

NX_Q6H3X3

Human splice variants

Protein structure