Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 14346-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14346-1-AP, RRID:AB_2214314
- Product name
- USP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated USP1 antibody (Cat. #14346-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references USP1 Promotes GC Metastasis via Stabilizing ID2.
USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.
USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1.
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma.
hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma.
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.
USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Li N, Wu L, Zuo X, Luo H, Sheng Y, Yan J
Disease markers 2021;2021:3771990
Disease markers 2021;2021:3771990
USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.
Han D, Wang L, Chen B, Zhao W, Liang Y, Li Y, Zhang H, Liu Y, Wang X, Chen T, Li C, Song X, Luo D, Li Z, Yang Q
Cell cycle (Georgetown, Tex.) 2021 Feb;20(3):320-331
Cell cycle (Georgetown, Tex.) 2021 Feb;20(3):320-331
USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1.
Li Y, Xu Y, Gao C, Sun Y, Zhou K, Wang P, Cheng J, Guo W, Ya C, Fan J, Yang X
Frontiers in oncology 2020;10:554809
Frontiers in oncology 2020;10:554809
Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma.
Zhao Y, Xue C, Xie Z, Ouyang X, Li L
Cell proliferation 2020 Oct;53(10):e12908
Cell proliferation 2020 Oct;53(10):e12908
hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma.
Herviou P, Le Bras M, Dumas L, Hieblot C, Gilhodes J, Cioci G, Hugnot JP, Ameadan A, Guillonneau F, Dassi E, Cammas A, Millevoi S
Nature communications 2020 May 27;11(1):2661
Nature communications 2020 May 27;11(1):2661
USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
Goldbraikh D, Neufeld D, Eid-Mutlak Y, Lasry I, Gilda JE, Parnis A, Cohen S
EMBO reports 2020 Apr 3;21(4):e48791
EMBO reports 2020 Apr 3;21(4):e48791
USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.
Huang X, Zhang Q, Lou Y, Wang J, Zhao X, Wang L, Zhang X, Li S, Zhao Y, Chen Q, Liang T, Bai X
Cancer immunology research 2019 Oct;7(10):1580-1590
Cancer immunology research 2019 Oct;7(10):1580-1590
USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.
Ma A, Tang M, Zhang L, Wang B, Yang Z, Liu Y, Xu G, Wu L, Jing T, Xu X, Yang S, Liu Y
Oncogene 2019 Mar;38(13):2405-2419
Oncogene 2019 Mar;38(13):2405-2419
The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
Ha K, Ma C, Lin H, Tang L, Lian Z, Zhao F, Li JM, Zhen B, Pei H, Han S, Malumbres M, Jin J, Chen H, Zhao Y, Zhu Q, Zhang P
Nature communications 2017 Jun 12;8:15751
Nature communications 2017 Jun 12;8:15751
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
Xiao H, Tian Y, Yang Y, Hu F, Xie X, Mei J, Ding F
Biochemical and biophysical research communications 2015 May 8;460(3):703-8
Biochemical and biophysical research communications 2015 May 8;460(3):703-8
A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.
Liang Q, Dexheimer TS, Zhang P, Rosenthal AS, Villamil MA, You C, Zhang Q, Chen J, Ott CA, Sun H, Luci DK, Yuan B, Simeonov A, Jadhav A, Xiao H, Wang Y, Maloney DJ, Zhuang Z
Nature chemical biology 2014 Apr;10(4):298-304
Nature chemical biology 2014 Apr;10(4):298-304
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ
Molecular cell 2012 Aug 10;47(3):396-409
Molecular cell 2012 Aug 10;47(3):396-409
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 14346-1-AP(USP1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The USP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human USP1. This antibody recognizes human,mouse,rat antigen. The USP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 14346-1-AP(USP1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue