BS8438

antibody from Bioworld Technology, Inc
Targeting: USP1
Provider product page for BS8438
Western blot
Immunohistochemistry

Antibody data

Product number
BS8438 - Provider product page
Provider
Bioworld Technology, Inc
Product name
USP1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human USP1.
Description
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP1 (ubiquitin specific peptidase 1), also known as UBP, ubiquitin carboxyl-terminal hydrolase 1, ubiquitin thioesterase 1 or deubiquitinating enzyme 1, is a 785 amino acid that belongs to the peptidase C19 family of ubiquitin carboxy-terminal hydrolases. A negative regulator of DNA damage repair, USP1 specifically deubiquitinates FANCD2 in the DNA repair pathway. Following DNA damage, autocatalytic cleavage of USP1 leads to an increase in ubiquitinated PCNA and the recruitment of POL H. Multiple isoforms of USP1 exist due to alternative splicing events.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
USP1 protein structure - BS8438 shown in red.