BS6809

antibody from Bioworld Technology, Inc
Targeting: IL23R IL-23R
Provider product page for BS6809
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6809 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL23R polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human IL23R.
Description
IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Also similar to IL-12, human IL-23 stimulates IFN-ÎÛ production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. The receptors for each appear to share one subunit, but also have at least one distinct subunit. Activated dendritic cells secrete detectable this heterodimeric complex and IL-23 binds to IL-12R beta 1 and IL-23R. At least six spliced isoforms of IL-23R (IL-23R1 to 6) can be generated through alternative splicing. The IL-23R2 and/or IL-23R4 variants are predominantly detected in certain human lung carcinomas and may contribute to their pathogenesis.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL23R protein structure - BS6809 shown in red.