Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS6809 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL23R polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IL23R.
- Description
- IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Also similar to IL-12, human IL-23 stimulates IFN-ÎÛ production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. The receptors for each appear to share one subunit, but also have at least one distinct subunit. Activated dendritic cells secrete detectable this heterodimeric complex and IL-23 binds to IL-12R beta 1 and IL-23R. At least six spliced isoforms of IL-23R (IL-23R1 to 6) can be generated through alternative splicing. The IL-23R2 and/or IL-23R4 variants are predominantly detected in certain human lung carcinomas and may contribute to their pathogenesis.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot analysis of IL23R polyclonal antibody